Gene Report

Basic Info

Approved Symbol	ANK3
Approved Name	ankyrin 3, node of Ranvier (ankyrin G)
Name Alias	"ankyrin-3, node of Ranvier\|ankyrin-G"
Location	10q21
Position	chr10:60026298-60733490, -1
External Links	HGNC: 494 Entrez Gene: 288 Ensembl: ENSG00000151150 UCSC: uc001jky.3
No. of Association Results	2 (Positive: 2; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Marker	Gene's Category
Logue, M. W.,2013	PTSD	rs1049862 - rs12357206 - rs10821659 - rs11813307, GGAA ; rs72818458 - rs28932171 - rs11599164 - rs17208576 - rs9804190 - rs7917800 - rs7098848, AGAAAAG ; rs1049862 ; rs10821659 ; rs11599164 ; rs11599447 ; rs11813307 ; rs12357206 ; rs17208576 ; rs28932171 ; rs7098848 ; rs72818458 ; rs7917800 ; rs9804190	Significant
Nievergelt, C. M.,2015	PTSD	rs139604943	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs139604943	Non-significant

Gene functional annotation

Gene related GO terms (count: 54)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0010628	positive regulation of gene expression	biological process	ISS[18180363]	14
GO:0005515	protein binding	molecular function	IPI[15231748\|15611082\|20195357]	169
GO:0000281	mitotic cytokinesis	biological process	IMP[14757759\|17620337]	2
GO:0007165	signal transduction	biological process	IEA	34
GO:0043001	Golgi to plasma membrane protein transport	biological process	IMP[17620337]	1
GO:0044267	cellular protein metabolic process	biological process	TAS	10
GO:0005886	plasma membrane	cellular component	ISS	99
GO:0016328	lateral plasma membrane	cellular component	IDA[14757759]	2
GO:0009986	cell surface	cellular component	ISS[21223964]	21
GO:0045296	cadherin binding	molecular function	ISS	4
GO:0007009	plasma membrane organization	biological process	IMP[17620337]	3
GO:0005794	Golgi apparatus	cellular component	IEA	17
GO:0005923	bicellular tight junction	cellular component	IDA[14757759]	5
GO:0033270	paranode region of axon	cellular component	IEA	1
GO:0030507	spectrin binding	molecular function	ISS	1
GO:0072661	protein targeting to plasma membrane	biological process	IMP[17620337]	1
GO:0043687	post-translational protein modification	biological process	TAS	6
GO:0045184	establishment of protein localization	biological process	IMP[15611082]	2
GO:0061024	membrane organization	biological process	TAS	6
GO:0010960	magnesium ion homeostasis	biological process	ISS	1
GO:0016323	basolateral plasma membrane	cellular component	IDA[15611082]	6
GO:0030315	T-tubule	cellular component	ISS	5
GO:0030674	protein binding, bridging	molecular function	ISS	2
GO:0014704	intercalated disc	cellular component	ISS	2
GO:0019228	neuronal action potential	biological process	ISS	2
GO:0005200	structural constituent of cytoskeleton	molecular function	IMP[17620337]	4
GO:2000651	positive regulation of sodium ion transmembrane transporter activity	biological process	ISS[18180363]	1
GO:0006888	ER to Golgi vesicle-mediated transport	biological process	TAS	3
GO:0042383	sarcolemma	cellular component	IDA[21223964]	7
GO:0072660	maintenance of protein location in plasma membrane	biological process	IGI[17620337]	1
GO:0043194	axon initial segment	cellular component	ISS	2
GO:0043266	regulation of potassium ion transport	biological process	ISS	2
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0008092	cytoskeletal protein binding	molecular function	ISS[21223964]	5
GO:0005829	cytosol	cellular component	TAS	78
GO:0009925	basal plasma membrane	cellular component	IDA[21223964]	2
GO:0072659	protein localization to plasma membrane	biological process	IGI[18180363]; IMP[14757759]	3
GO:0005783	endoplasmic reticulum	cellular component	TAS[8666667]	20
GO:0007411	axon guidance	biological process	IEA	16
GO:0007409	axonogenesis	biological process	ISS	6
GO:0014731	spectrin-associated cytoskeleton	cellular component	ISS	1
GO:0033268	node of Ranvier	cellular component	ISS	1
GO:0007016	cytoskeletal anchoring at plasma membrane	biological process	TAS[7836469]	1
GO:0010765	positive regulation of sodium ion transport	biological process	ISS[18180363]	2
GO:0071709	membrane assembly	biological process	IMP[14757759\|17620337]	1
GO:0050808	synapse organization	biological process	IEA	1
GO:0018279	protein N-linked glycosylation via asparagine	biological process	TAS	5
GO:0045838	positive regulation of membrane potential	biological process	ISS[18180363]	1
GO:0071286	cellular response to magnesium ion	biological process	ISS	1
GO:1900827	positive regulation of membrane depolarization during cardiac muscle cell action potential	biological process	ISS[18180363]	1
GO:0043034	costamere	cellular component	TAS[21223964]	1
GO:0005764	lysosome	cellular component	IEA	4
GO:0044325	ion channel binding	molecular function	ISS	5
GO:1902260	negative regulation of delayed rectifier potassium channel activity	biological process	ISS	1

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 8)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
ANK3	SPTBN4	No	--	--	11807096 , 11807096 , 11807096
ANK3	SMAD2	No	--	--	15231748 , 20195357 , 15231748 , 15231748
ANK3	HOOK1	No	--	--	15823567
ANK3	FADD	No	--	--	14694156
ANK3	SCN2A	No	--	--	12036953 , 14761957
ANK3	MAPK6	No	--	--	20936779 , 20936779
ANK3	RNF2	No	--	--	24457600
ANK3	TIAM1	No	--	--	10893266 , 10893266