Gene Report

Basic Info

Approved Symbol	GABRA2
Approved Name	gamma-aminobutyric acid (GABA) A receptor, alpha 2
Name Alias	GABA(A) receptor, alpha 2
Location	4p12
Position	chr4:46248427-46475230, -1
External Links	HGNC: 4076 Entrez Gene: 2555 Ensembl: ENSG00000151834 UCSC: uc010igc.3
No. of Association Results	3 (Positive: 1; Negative: 2; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 3)

Reference	Phenotype	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	rs148139959	Significant
Solovieff, N.,2014	PTSD diagnosis	rs693547	Non-significant
Solovieff, N.,2014	PTSD severity	rs17537141	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs148139959	Non-significant

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:1902711	GABA-A receptor complex	cellular component	IBA	2
GO:0030424	axon	cellular component	IEA	16
GO:1902476	chloride transmembrane transport	biological process	IEA	3
GO:0030054	cell junction	cellular component	IEA	24
GO:0007214	gamma-aminobutyric acid signaling pathway	biological process	IMP[8391122]	4
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0099565	chemical synaptic transmission, postsynaptic	biological process	IMP[8391122]	7
GO:0055085	transmembrane transport	biological process	TAS	14
GO:0005254	chloride channel activity	molecular function	IEA	3
GO:0004890	GABA-A receptor activity	molecular function	IBA	2
GO:0006836	neurotransmitter transport	biological process	IMP[8391122]	1
GO:0034220	ion transmembrane transport	biological process	TAS	9
GO:0030285	integral component of synaptic vesicle membrane	cellular component	IDA[8391122]	1
GO:0005230	extracellular ligand-gated ion channel activity	molecular function	IEA	2
GO:0001505	regulation of neurotransmitter levels	biological process	IMP[8391122]	1
GO:0034707	chloride channel complex	cellular component	IEA	3
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0008503	benzodiazepine receptor activity	molecular function	IMP[8391122]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 1)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
GABRA2	MDM2	No	--	--	20195357