Study Report
Study Information
Basic Info
| Reference |
Telch, M. J.,2015 PMID: 26043338
|
| Citation |
Telch, M. J., et al. (2015). "5-HTTLPR genotype potentiates the effects of war zone stressors on the emergence of PTSD, depressive and anxiety symptoms in soldiers deployed to iraq." World Psychiatry 14(2): 198-206. |
| Phenotype |
PTSD |
| Trauma |
Iraq combat |
| Study Design |
Cross-sectional study |
| Study Type |
Candidate gene association study, Gene-environment interaction study |
| Sample Size |
133 samples |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian, Black, Mongloid |
| Population |
Participants were predominantly Caucasian (72.9%), of which 24 (18% of the total sample) were Hispanic. Other ethnic/racial groups included African-Americans (9.8%), American Indians (12.8%), and Asian/Pacific Islanders (4.5%). |
| Gender |
85.7% males, 14.3% females |
| Age |
Mean age=23.5 years, SD=6.0 |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Structured Clinical Interview for DSM-IV(SCID-I), Combat Experiences Log (CEL), 4-item PTSD Checklist (PCL-Short), 10-item version of the Center for Epidemiologic Studies Depression Scale (CES-D), |
| Sample Status |
At pre-deployment, 20 (15.0%) participants met criteria for one or more current Axis I diagnoses, including substance use disorder (n=7, 5.3%), anxiety disorder (n=9, 6.8%), mooddisorder(n=6,4.5%), andadjustmentdisorder (n=5,3.8%). |
| Controls Exposed |
NA |
| Replication Size |
None |
| Result Summary |
Soldiers carrying one or two low functioning alleles (S or LG) reported heightened symptoms of PTSD, depression and anxiety in response to increased levels of exposure to war zone stressors, relative to soldiers homozygous for the high functioning allele (LA).The results provide novel evidence for an association between 5-HTTLPR genotype, level of exposure to war zone stressors, and symptoms of PTSD, depression and anxiety among soldiers deployed to a war zone. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
PTSD |
SLC6A4 |
B=-0.18, P-value>0.55 |
There was no significant main effect of 5-HTTLPR genotype on......
There was no significant main effect of 5-HTTLPR genotype on any of the three indices of war zone stress reactions.
More...
|
Non-significant |
Gene * Environment result reported by this study (count: 3)
| Marker |
Phenotype |
Related Gene |
Environment |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
PTSD |
SLC6A4 |
Average level of war zone stressors |
MRM analyses: genotype: b=0.21, t=2.08, P-value<0.05. Separately for S' carriers: b=0.28, t=4.01, P-value<0.0001. Separately for L' homozygote: b=0.07, t=0.86, P-value>0.39. |
MRM analyses revealed significant interactions between 5-HTT......
MRM analyses revealed significant interactions between 5-HTTLPR genotype and average level of war zone stressors during deployment for all three measures of war zone stress reactions. For L' homozygotes, higher levels of average stress reported in the ?eld did not predict higher symptoms, In contrast, and consistent with our hypothesis, S' carriers responded to higher levels of average stress with higher levels of PTSD symptoms.
More...
|
Significant |
|
5-HTTLPR
|
PTSD |
SLC6A4 |
Average level of war zone stressors, Race |
Three way interaction: p-values ranged between 0.17 and 0.47 |
The race x war zone stressors x 5-HTTLPR genotype interactio......
The race x war zone stressors x 5-HTTLPR genotype interaction for PTSD was not significant, indicating that the observed war zone stressors x 5-HTTLPR genotype interactions were not influenced by soldiers'race.
More...
|
Non-significant |
|
5-HTTLPR
|
PTSD |
SLC6A4 |
Change in stress |
MRM analyses: genotype: b=-0.14, P-value>0.05 |
Not significant effect.
Not significant effect.
|
Non-significant |
