Gene Report

Basic Info

Approved Symbol	CRHR2
Symbol Alias	"CRF2\|CRF-RB\|HM-CRF"
Approved Name	corticotropin releasing hormone receptor 2
Location	7p14.3
Position	chr7:30651943-30700129, -1
External Links	HGNC: 2358 Entrez Gene: 1395 Ensembl: ENSG00000106113 UCSC: uc003tbp.3
No. of Association Results	2 (Positive: 2; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 2)

Reference	Phenotype	Marker	Gene's Category
Wolf, E. J.,2013	Latent PTSD Severity	rs2190242 ; rs2267715 ; rs2284218 ; rs8192496	Significant
Wolf, E. J.,2013	PTSD diagnosis	rs2190242 ; rs2240404 ; rs2267715 ; rs2267717 ; rs2284216 ; rs2284218 ; rs2284220 ; rs3779250 ; rs8192496 ; rs973002	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Wolf, E. J.,2013	Latent PTSD Severity	Lifetime trauma exposure	rs2190242 ; rs8192496	Non-significant

Gene functional annotation

Gene related GO terms (count: 51)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0070372	regulation of ERK1 and ERK2 cascade	biological process	IEA	1
GO:0007015	actin filament organization	biological process	IEA	3
GO:0007166	cell surface receptor signaling pathway	biological process	IEA	16
GO:0043196	varicosity	cellular component	IEA	2
GO:0032755	positive regulation of interleukin-6 production	biological process	IEA	5
GO:0060291	long-term synaptic potentiation	biological process	IEA	5
GO:0043951	negative regulation of cAMP-mediated signaling	biological process	IEA	2
GO:0021854	hypothalamus development	biological process	IEA	2
GO:0030818	negative regulation of cAMP biosynthetic process	biological process	IEA	3
GO:0033685	negative regulation of luteinizing hormone secretion	biological process	IEA	1
GO:0042423	catecholamine biosynthetic process	biological process	IEA	3
GO:0010700	negative regulation of norepinephrine secretion	biological process	IEA	1
GO:0030425	dendrite	cellular component	IEA	19
GO:0010460	positive regulation of heart rate	biological process	IEA	1
GO:0014064	positive regulation of serotonin secretion	biological process	IEA	1
GO:0046882	negative regulation of follicle-stimulating hormone secretion	biological process	IEA	1
GO:0045777	positive regulation of blood pressure	biological process	IEA	3
GO:0090281	negative regulation of calcium ion import	biological process	IEA	1
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	biological process	IEA	2
GO:0071376	cellular response to corticotropin-releasing hormone stimulus	biological process	IEA	2
GO:2000252	negative regulation of feeding behavior	biological process	IEA	1
GO:0030855	epithelial cell differentiation	biological process	IEA	3
GO:0015056	corticotrophin-releasing factor receptor activity	molecular function	IEA	2
GO:2000293	negative regulation of defecation	biological process	IEA	1
GO:0010629	negative regulation of gene expression	biological process	IEA	3
GO:0048630	skeletal muscle tissue growth	biological process	IEA	1
GO:0021549	cerebellum development	biological process	IEA	3
GO:0070852	cell body fiber	cellular component	IEA	4
GO:0005791	rough endoplasmic reticulum	cellular component	IEA	2
GO:0030819	positive regulation of cAMP biosynthetic process	biological process	IEA	2
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	TAS[8536644]	3
GO:0043404	corticotropin-releasing hormone receptor activity	molecular function	IEA	1
GO:0032874	positive regulation of stress-activated MAPK cascade	biological process	IEA	1
GO:0043679	axon terminus	cellular component	IEA	6
GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus	biological process	IEA	1
GO:0005794	Golgi apparatus	cellular component	IEA	17
GO:0043950	positive regulation of cAMP-mediated signaling	biological process	IEA	1
GO:0035482	gastric motility	biological process	IEA	1
GO:0051092	positive regulation of NF-kappaB transcription factor activity	biological process	IEA	8
GO:0009986	cell surface	cellular component	IEA	21
GO:0032811	negative regulation of epinephrine secretion	biological process	IEA	1
GO:0019233	sensory perception of pain	biological process	IEA	9
GO:0009755	hormone-mediated signaling pathway	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[11329063]	169
GO:0017046	peptide hormone binding	molecular function	IEA	3
GO:0043204	perikaryon	cellular component	IEA	6
GO:0016525	negative regulation of angiogenesis	biological process	IEA	4
GO:0071385	cellular response to glucocorticoid stimulus	biological process	IEA	3
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0005179	hormone activity	molecular function	IEA	2
GO:0005887	integral component of plasma membrane	cellular component	TAS[8536644]	36

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 2)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CRHR2	UCN2	No	--	--	11416224
CRHR2	UCN3	No	--	--	11329063