PTSDgene database

SNP Report

Basic Info
Name rs10038727 dbSNP Ensembl
Location 5:168459532 - 168459532(+)
Variant Seq A
Ancestral Allele G
Ref Seq G
Minor Allele Frequence 0.256789
Annotation intron_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000524228, ENST00000521089, ENST00000619752, ENST00000265293, ENST00000524038, ENST00000522140, ENST00000393895); non_coding_transcript_variant(ENST00000522140)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000524038, ENST00000393895, ENST00000619752, ENST00000521089, ENST00000265293, ENST00000524228)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000524038, ENST00000393895, ENST00000619752, ENST00000521089, ENST00000265293, ENST00000524228)
rSNP? Yes Link in rVarBase
Related Regulatory Elements Chromatin interactive region
Chromatin State Weak transcription;Strong transcription
No. of Marker's Association Results 5 (Positive: 5; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 5)
Reference Phenotype Statistical Values Author Comments Marker's Category
Wilker, S.,2013 Current PTSD In Rwandan Sample: no detail information, In the Ugandan sa...... In Rwandan Sample: no detail information, In the Ugandan sample: LR= 4.58, P-value= 0.03, OR= 0.31 [95% CI= 0.10-0.99] More... In the Ugandan sample, an strong association of the SNP wit...... In the Ugandan sample, an strong association of the SNP with current PTSD was observed. More... Significant
Sumner, J. A.,2014 Lifetime PTSD Odds ratio (OR) =0.64 [95% confidence interval (CI)= 0.406-0...... Odds ratio (OR) =0.64 [95% confidence interval (CI)= 0.406-0.997], P-value= 0.049 More... The WWC1 rs10038727 SNP (coded additively) significantly pre...... The WWC1 rs10038727 SNP (coded additively) significantly predicted lifetime PTSD status, with the minor (A) allele associated with a reduced risk of PTSD. More... Significant
Wilker, S.,2013 PDS hyperarousal score In Rwandan Sample: no detail information, In the Ugandan sa...... In Rwandan Sample: no detail information, In the Ugandan sample: Exclusion of one outlier: LR= 5.24, P-value= 0.02 More... The SNP has a significant association with the PDS hyperarou...... The SNP has a significant association with the PDS hyperarousal score. More... Significant
Wilker, S.,2013 PDS intrusion score In Rwandan Sample: did not survive multiple comparison corr...... In Rwandan Sample: did not survive multiple comparison correction, In the Ugandan sample: Exclusion of one outlier: LR= 5.07, P-value= 0.02 More... The SNP has a significant association with the PDS intrusion...... The SNP has a significant association with the PDS intrusion score. More... Significant
Wilker, S.,2013 PTSD diagnosis In Rwandan Sample: nominal association P-value=0.000075 In Rwandan Sample: nominal association P-value=0.000075 Remain significant after correcting for multiple comparisons...... Remain significant after correcting for multiple comparisons. Minor allele carriers of rs10038727 displayed a reduced risk toward lifetime PTSD development. More... Significant
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Sumner, J. A.,2014 Lifetime PTSD Lifetime traumatic load P-value= 0.65 P-value= 0.65 We did not find evidence of a significant interaction betwee...... We did not find evidence of a significant interaction between rs10038727 genotype and lifetime traumatic load in predicting lifetime PTSD status. More... Non-significant


SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
WWC1 WW and C2 domain containing 1 5q34 6(6/0/0)
RARS arginyl-tRNA synthetase 5q35.1 rSNP target

SNPs in LD with rs10038727 (count: 27)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 26)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1-IT1 Yes Adipose Subcutaneous cis GTEx