Gene Report

Basic Info

Approved Symbol	JAK1
Previous Symbol	JAK1B
Symbol Alias	"JAK1A\|JTK3"
Approved Name	Janus kinase 1
Location	1p32.3-p31.3
Position	chr1:64833229-64966504, -1
External Links	HGNC: 6190 Entrez Gene: 3716 Ensembl: ENSG00000162434 UCSC: uc001dbu.1
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	rs4916008	Trend

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs4916008	Non-significant

Gene functional annotation

Gene related GO terms (count: 44)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0012505	endomembrane system	cellular component	IEA	2
GO:0030154	cell differentiation	biological process	IBA	10
GO:0005524	ATP binding	molecular function	IEA	23
GO:0042127	regulation of cell proliferation	biological process	IBA	2
GO:0000165	MAPK cascade	biological process	TAS	10
GO:0004715	non-membrane spanning protein tyrosine kinase activity	molecular function	IBA	2
GO:0005925	focal adhesion	cellular component	IDA[21423176]	11
GO:0046677	response to antibiotic	biological process	IDA[16280321]	2
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	11
GO:0045087	innate immune response	biological process	IBA; TAS	15
GO:0019903	protein phosphatase binding	molecular function	IPI[11909529]	2
GO:0038110	interleukin-2-mediated signaling pathway	biological process	IDA[11909529]	2
GO:0008286	insulin receptor signaling pathway	biological process	TAS	8
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	8
GO:0005131	growth hormone receptor binding	molecular function	ISS[10502458]	1
GO:0035556	intracellular signal transduction	biological process	TAS[8232552]	10
GO:0007265	Ras protein signal transduction	biological process	TAS	8
GO:0007411	axon guidance	biological process	TAS	16
GO:0005737	cytoplasm	cellular component	IDA[10502458]	109
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	11
GO:0005634	nucleus	cellular component	IDA[10502458]	81
GO:0048010	vascular endothelial growth factor receptor signaling pathway	biological process	TAS	9
GO:0005102	receptor binding	molecular function	IBA	13
GO:0005856	cytoskeleton	cellular component	IEA	12
GO:0000186	activation of MAPKK activity	biological process	TAS	7
GO:0036016	cellular response to interleukin-3	biological process	IEA	1
GO:0005829	cytosol	cellular component	TAS	78
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	IBA	4
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	9
GO:0060338	regulation of type I interferon-mediated signaling pathway	biological process	TAS	1
GO:0060334	regulation of interferon-gamma-mediated signaling pathway	biological process	TAS	2
GO:0031730	CCR5 chemokine receptor binding	molecular function	IEA	1
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS	9
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	cellular component	IBA	2
GO:0060337	type I interferon signaling pathway	biological process	TAS	3
GO:0038083	peptidyl-tyrosine autophosphorylation	biological process	IBA	2
GO:0005515	protein binding	molecular function	IPI[7759950\|16273093\|16710296]	169
GO:1903672	positive regulation of sprouting angiogenesis	biological process	IGI[20299512]	1
GO:0016477	cell migration	biological process	IBA	6
GO:0060333	interferon-gamma-mediated signaling pathway	biological process	TAS	5
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	14
GO:0004713	protein tyrosine kinase activity	molecular function	EXP; TAS	2
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[24882218]	6
GO:0006468	protein phosphorylation	biological process	TAS[1848670]	7

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa04630	Jak-STAT signaling pathway	5
hsa05212	Pancreatic cancer	3
hsa04920	Adipocytokine signaling pathway	4

Gene related interactors from protein-protein interactions data in PINA v2 (count: 59)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
JAK1	SMURF1	No	--	--	23184937
JAK1	IL9R	No	--	--	8756628 , 8756628
JAK1	IFNAR2	No	--	--	16710296 , 16710296 , 12133952 , 16710296 , 16710296 , 16710296 , 16710296 , 16710296 , 16710296 , 16710296 , 16710296 , 16710296 , 12133952
JAK1	TEC	No	--	--	9178903 , 9178903
JAK1	IL2RG	No	--	--	8041779 , 7973658
JAK1	MDM2	No	--	--	24413661 , 24413661
JAK1	IL4R	No	--	--	12242343 , 12133952 , 12133952
JAK1	HIST3H3	No	--	--	21151131
JAK1	CSF3R	No	--	--	7512720 , 7512720
JAK1	ARRB1	Yes	--	--	17353931
JAK1	MAGOH	No	--	--	23084401
JAK1	SHB	No	--	--	12200137 , 12200137
JAK1	IL6ST	No	--	--	11468294 , 11468294 , 9388212 , 11468294 , 9388212 , 11742534 , 11557047
JAK1	STAT2	No	--	--	9020188
JAK1	STAT6	No	--	--	9651359 , 10856136
JAK1	ABL2	No	--	--	9774693
JAK1	ELP2	No	--	--	10954736 , 10954736 , 10954736
JAK1	IL10RA	No	--	--	12133952 , 12133952 , 12374810
JAK1	EIF4A3	No	--	--	23084401
JAK1	TYK2	No	--	--	7589562 , 7589562
JAK1	GNB2L1	No	--	--	12960323 , 12960323 , 12960323
JAK1	IL5RA	No	--	--	9516124 , 9516124
JAK1	IL3RA	No	--	--	15988755
JAK1	GRB2	No	--	--	11527382 , 8536716 , 11527382
JAK1	BRCA1	No	coimmunoprecipitation	--	11163768 , 11163768 , 11163768 , 11163768 , 11163768
JAK1	IRS1	No	--	--	9492017 , 7499365 , 11162588
JAK1	PRKCZ	No	--	--	15526032
JAK1	EIF2C4	No	--	association	19167051 , 19167051
JAK1	ELF3	No	--	--	17353931
JAK1	PIK3R1	No	--	--	9774657
JAK1	ATIC	No	--	--	17353931
JAK1	OSMR	No	--	--	10586060
JAK1	TIRAP	No	--	association	21903422 , 21903422 , 21903422
JAK1	SYK	No	--	--	10825200
JAK1	JAKMIP1	No	--	--	15277531
JAK1	PTPN11	No	--	--	12403768 , 8995399 , 8995399 , 8995399
JAK1	CXCR4	No	--	--	12163560
JAK1	BTK	No	--	--	9178903 , 9178903
JAK1	IL27RA	No	--	--	12734330
JAK1	STAT5B	No	--	--	9047382 , 9047382 , 9047382
JAK1	STAT3	No	--	--	15284024 , 11722592 , 11722592 , 11751884
JAK1	CCR1	No	--	--	14674010
JAK1	CCR5	No	--	--	10037796
JAK1	SIRT1	No	--	--	22542455
JAK1	PTK2B	Yes	--	--	10702271 , 10702271 , 10702271
JAK1	PLAUR	No	coimmunoprecipitation	--	9417082 , 9417082 , 9417082
JAK1	NOC2L	No	--	--	24413661
JAK1	IL21R	No	--	--	11016959 , 11016959
JAK1	PTPN6	No	--	--	7629131 , 7629131
JAK1	STAM	No	--	--	9133424
JAK1	CSF2RB	No	--	--	11557047 , 21965659
JAK1	JAK3	No	--	--	9553136 , 12207328 , 11557047
JAK1	IRS2	No	--	--	7499365 , 7499365
JAK1	INPP5D	No	--	--	10875931
JAK1	STAT1	No	--	--	14978237 , 15284024 , 11722592
JAK1	PML	No	--	--	20409569
JAK1	TAGLN	No	--	--	22798525
JAK1	PLA2G4A	No	--	--	8612580 , 8612580 , 8612580
JAK1	STAT5A	No	--	--	11722592 , 9047382 , 9047382 , 9047382 , 9047382