Gene Report

Basic Info

Approved Symbol	DTNBP1
Symbol Alias	"Dysbindin\|My031\|HPS7\|DBND\|BLOC1S8"
Approved Name	dystrobrevin binding protein 1
Name Alias	"dysbindin-1\|biogenesis of lysosomal organelles complex-1, subunit 8"
Location	6p22.3
Position	chr6:15522801-15663058, -1
External Links	HGNC: 17328 Entrez Gene: 84062 Ensembl: ENSG00000047579 UCSC: uc003nbm.3
No. of Association Results	5 (Positive: 2; Negative: 3; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 5)

Reference	Phenotype	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	rs116647843	Non-significant
Voisey, J.,2010	PTSD	rs9370822	Significant
Voisey, J.,2010	PTSD	rs9370822	Significant
Solovieff, N.,2014	PTSD diagnosis	rs1011313	Non-significant
Solovieff, N.,2014	PTSD severity	rs3213207	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs116647843	Non-significant

Gene functional annotation

Gene related GO terms (count: 33)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0014069	postsynaptic density	cellular component	IDA[16980328]	11
GO:0043005	neuron projection	cellular component	IDA[16980328]	17
GO:0005515	protein binding	molecular function	IPI[15102850\|19349376\|20921223\|22203680\|23414517\|25416956]	169
GO:0060155	platelet dense granule organization	biological process	IEA	2
GO:0016528	sarcoplasm	cellular component	IEA	1
GO:0006892	post-Golgi vesicle-mediated transport	biological process	TAS	3
GO:0030672	synaptic vesicle membrane	cellular component	IDA[16980328]; ISS	3
GO:0030424	axon	cellular component	ISS	16
GO:0008089	anterograde axonal transport	biological process	ISS	3
GO:0007596	blood coagulation	biological process	IEA	11
GO:0005789	endoplasmic reticulum membrane	cellular component	ISS	13
GO:0048490	anterograde synaptic vesicle transport	biological process	ISS	2
GO:0010628	positive regulation of gene expression	biological process	ISS	14
GO:0031532	actin cytoskeleton reorganization	biological process	ISS	1
GO:0030426	growth cone	cellular component	ISS	4
GO:0030054	cell junction	cellular component	IEA	24
GO:0048812	neuron projection morphogenesis	biological process	ISS	1
GO:0031175	neuron projection development	biological process	IDA[16980328]	8
GO:0014059	regulation of dopamine secretion	biological process	ISS	6
GO:0010008	endosome membrane	cellular component	IEA	6
GO:0031083	BLOC-1 complex	cellular component	IDA[15102850\|22203680]	2
GO:0043506	regulation of JUN kinase activity	biological process	IEA	1
GO:0032438	melanosome organization	biological process	NAS[22203680]	2
GO:0005829	cytosol	cellular component	TAS	78
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0033162	melanosome membrane	cellular component	IEA	2
GO:0005737	cytoplasm	cellular component	ISS	109
GO:0005634	nucleus	cellular component	ISS	81
GO:0042383	sarcolemma	cellular component	ISS	7
GO:0060159	regulation of dopamine receptor signaling pathway	biological process	ISS	1
GO:0001956	positive regulation of neurotransmitter secretion	biological process	ISS	1
GO:0043197	dendritic spine	cellular component	ISS	9
GO:0061024	membrane organization	biological process	TAS	6

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 13)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
DTNBP1	ZFYVE20	No	--	--	17043677 , 17043677
DTNBP1	ZNF490	No	--	--	17043677 , 17043677
DTNBP1	BLOC1S6	No	biochemical	association	12191018 , 15102850 , 22203680 , 22203680 , 22203680 , 15102850 , 15102850 , 15102850 , 15102850 , 15102850 , 15102850 , 15102850 , 15102850
DTNBP1	OSBPL9	No	--	--	19615732 , 19615732
DTNBP1	DTNA	No	--	--	11316798
DTNBP1	ABI3	No	--	--	16189514 , 16189514 , 16189514 , 16189514 , 16189514
DTNBP1	TRIM2	No	--	--	17043677
DTNBP1	MACF1	No	--	--	17043677 , 17043677
DTNBP1	DGCR6L	No	--	--	16189514 , 16189514 , 16189514
DTNBP1	SYBU	No	--	--	17043677 , 17043677
DTNBP1	EXOC7	No	--	--	17043677
DTNBP1	TRIM9	No	--	--	17043677
DTNBP1	NUF2	No	--	--	17043677