PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Lowe, S. R.,2015 PMID: 25798337
Citation	Lowe, S. R., et al. (2015). "RORA and posttraumatic stress trajectories: main effects and interactions with childhood physical abuse history." Brain Behav 5(4): e00323.
Phenotype	High versus low posttraumatic stress trajectory, Increasing versus low posttraumatic stress trajectory, Decreasing versus low posttraumatic stress trajectory, Increasing versus decreasing posttraumatic stress trajectory
Trauma	Not mentioned.
Study Design	Case-control (longitudinal design)
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	473 adults
SNP/Marker Size	2 SNPs
Predominant Ethnicity	Black
Population	Non-Hispanic Black
Gender	57.5% female
Age	Mean age=53.35 years, SD=15.58.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	PTSD Checklist-Civilian Version, Clinician-Administered PTSD Scale, Conflicts Tactics Scale (CTS)
Sample Status	Data were from the genetic sample of the Detroit Neighborhood Health Study (DNHS), a longitudinal population-based study of predominantly non-Hispanic Black adults (18 years or older) living in Detroit, Michigan.
Controls Exposed	Not mentioned.
Replication Size	None
Result Summary	We found that the minor allele of the RORA SNP rs893290 was a significant predictor of membership in a trajectory of consistently high PTS, relatively to a trajectory of consistently low PTS. Additionally, the GxE of rs893290 with childhood physical abuse was significant. Decomposition of the interaction showed that minor allele frequency was more strongly associated with membership in consistently high or decreasing PTS trajectories, relative to a consistently low PTS trajectory, among participants with higher levels of childhood physical abuse. The results of the study provide preliminary evidence that variation in the RORA gene is associated with membership in trajectories of higher PTS and that these associations are stronger among persons exposed to childhood physical abuse. Replication and analysis of functional data are needed to further our understanding of how RORA relates to PTS trajectories.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 2)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs893290	High versus low posttraumatic stress trajectory	RORA	Main effects of RORA SNPs on trajectory membership (controlling for age, gender, and ancestry): OR=3.64, P-value<0.01.	For rs893290, having one or more copies of the minor allele ...... For rs893290, having one or more copies of the minor allele was associated with a greater likelihood of being in the high trajectory, relative to the low trajectory, a result that remained significant after correction for multiple testing. More...	Significant
rs16942660	Increasing versus decreasing posttraumatic stress trajectory	RORA	Main effects of RORA SNPs on trajectory membership (controlling for age, gender, and ancestry): OR=3.13, P-value<0.05.	rs16942660, having one or more copies of the minor allele wa...... rs16942660, having one or more copies of the minor allele was significantly associated with a greater likelihood of being in the increasing trajectory, relative to the decreasing trajectory. However, this result did not hold after correction for multiple testing. More...	Significant

Gene * Environment result reported by this study (count: 3)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs893290	High versus low posttraumatic stress trajectory	RORA	Childhood physical abuse	Interaction between rs893290 and childhood physical abuse: OR=1.32, P-value<0.05.	The interaction between rs893290 and childhood physical abus...... The interaction between rs893290 and childhood physical abuse was significantly predictive of membership in the high trajectories, relative to the low trajectory. With correction for multiple testing, the interaction remained a significant predictor of high trajectories, relative to the low trajectory. More...	Significant
rs893290	Decreasing versus low posttraumatic stress trajectory	RORA	Childhood physical abuse	Interaction between rs893290 and childhood physical abuse: OR=1.22, P-value<0.05.	The interaction between rs893290 and childhood physical abus...... The interaction between rs893290 and childhood physical abuse was significantly predictive of membership in the decreasing trajectories, relative to the low trajectory. With correction for multiple testing, the interaction remained a significant predictor of decreasing trajectories, relative to the low trajectory. More...	Significant
rs893290	Increasing versus low posttraumatic stress trajectory	RORA	Childhood physical abuse	Interaction between rs893290 and childhood physical abuse: OR=1.46, P-value<0.05.	The interaction between rs893290 and childhood physical abus...... The interaction between rs893290 and childhood physical abuse was significantly predictive of membership in the increasing trajectories, relative to the low trajectory. More...	Significant