PTSDgene database

Gene Report

Basic Info
Approved Symbol COMT
Approved Name catechol-O-methyltransferase
Location 22q11.21
Position chr22:19941607-19969975, 1
External Links HGNC: 2228
Entrez Gene: 1312
Ensembl: ENSG00000093010
UCSC: uc002zqu.3
No. of Association Results 21 (Positive: 9; Negative: 12; trend: 0)
Annotation Type Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy
Gene related association results
Normal genetic study related association results (count: 21)
Reference Phenotype Marker Gene's Category
Winkler, E. A.,2017 PTSD diagnosis rs4680 Significant
Hayes, J. P.,2017 CAPS score rs4680 Non-significant
van Rooij, S. J.,2016 PTSD symptom severity rs4680 Non-significant
van Rooij, S. J.,2016 PTSD intrusive symptoms rs4680 Non-significant
van Rooij, S. J.,2016 PTSD avoidance/numbing symptoms rs4680 Non-significant
van Rooij, S. J.,2016 PTSD hyperarousal symptoms rs4680 Non-significant
Goenjian, A. K.,2014 B category score rs4633 ; rs4680 ; rs4818 ; rs6269 Non-significant
Goenjian, A. K.,2014 C category score rs4633 ; rs4680 ; rs4818 ; rs6269 Significant
Valente, N. L.,2011 CAPS scores rs4680 Significant
Goenjian, A. K.,2014 D category score rs4633 ; rs4680 ; rs4818 ; rs6269 Significant
Wolf, E. J.,2014 Dissociative symptom severity rs9306235 Non-significant
Kolassa, I. T.,2010 Lifetime PTSD rs4680 Non-significant
Nievergelt, C. M.,2015 PTSD rs174686 Significant
Valente, N. L.,2011 PTSD rs4680 Significant
Humphreys, K. L.,2014 PTSD category D symptom rs4680 Significant
Solovieff, N.,2014 PTSD diagnosis rs165774 Non-significant
Humphreys, K. L.,2014 PTSD diagnosis rs4680 Non-significant
Solovieff, N.,2014 PTSD severity rs165774 Non-significant
Clark, R.,2013 PTSD symptoms (combined scores for severity and frequency) rs4680 Non-significant
Goenjian, A. K.,2014 Total PTSD symptom severity score rs4633 ; rs4680 ; rs4818 ; rs6269 Significant
Humphreys, K. L.,2014 Total PTSD symptoms rs4680 Significant
G*E study related association result (count: 1)
Reference Phenotype Environment Marker Gene's Category
Kolassa, I. T.,2010 Probability of developing lifetime PTSD Traumatic load rs4680 ; rs174686 Significant
Gene functional annotation
Gene related GO terms (count: 37)

Gene related KEGG pathways (count: 1)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 9)