
Gene Report
Approved Symbol | COMT |
---|---|
Approved Name | catechol-O-methyltransferase |
Location | 22q11.21 |
Position | chr22:19941607-19969975, 1 |
External Links |
HGNC: 2228 Entrez Gene: 1312 Ensembl: ENSG00000093010 UCSC: uc002zqu.3 |
No. of Association Results | 21 (Positive: 9; Negative: 12; trend: 0) |
Annotation Type | Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy |
Reference | Phenotype | Marker | Gene's Category |
---|---|---|---|
Winkler, E. A.,2017 | PTSD diagnosis | rs4680 | Significant |
Hayes, J. P.,2017 | CAPS score | rs4680 | Non-significant |
van Rooij, S. J.,2016 | PTSD symptom severity | rs4680 | Non-significant |
van Rooij, S. J.,2016 | PTSD intrusive symptoms | rs4680 | Non-significant |
van Rooij, S. J.,2016 | PTSD avoidance/numbing symptoms | rs4680 | Non-significant |
van Rooij, S. J.,2016 | PTSD hyperarousal symptoms | rs4680 | Non-significant |
Goenjian, A. K.,2014 | B category score | rs4633 ; rs4680 ; rs4818 ; rs6269 | Non-significant |
Goenjian, A. K.,2014 | C category score | rs4633 ; rs4680 ; rs4818 ; rs6269 | Significant |
Valente, N. L.,2011 | CAPS scores | rs4680 | Significant |
Goenjian, A. K.,2014 | D category score | rs4633 ; rs4680 ; rs4818 ; rs6269 | Significant |
Wolf, E. J.,2014 | Dissociative symptom severity | rs9306235 | Non-significant |
Kolassa, I. T.,2010 | Lifetime PTSD | rs4680 | Non-significant |
Nievergelt, C. M.,2015 | PTSD | rs174686 | Significant |
Valente, N. L.,2011 | PTSD | rs4680 | Significant |
Humphreys, K. L.,2014 | PTSD category D symptom | rs4680 | Significant |
Solovieff, N.,2014 | PTSD diagnosis | rs165774 | Non-significant |
Humphreys, K. L.,2014 | PTSD diagnosis | rs4680 | Non-significant |
Solovieff, N.,2014 | PTSD severity | rs165774 | Non-significant |
Clark, R.,2013 | PTSD symptoms (combined scores for severity and frequency) | rs4680 | Non-significant |
Goenjian, A. K.,2014 | Total PTSD symptom severity score | rs4633 ; rs4680 ; rs4818 ; rs6269 | Significant |
Humphreys, K. L.,2014 | Total PTSD symptoms | rs4680 | Significant |
Reference | Phenotype | Environment | Marker | Gene's Category |
---|---|---|---|---|
Kolassa, I. T.,2010 | Probability of developing lifetime PTSD | Traumatic load | rs4680 ; rs174686 | Significant |
ID | Name | No. of Genes in PTSDgene |
---|---|---|
hsa00350 | Tyrosine metabolism | 5 |
Gene | Interactor | Interactor in PTSDgene? | Experiment Method | Interaction Type | PMID |
---|---|---|---|---|---|
COMT | VCP | No | -- | -- | 23383273 |
COMT | MCC | No | -- | -- | 17353931 |
COMT | RNF2 | No | -- | -- | 24457600 |
COMT | XRN2 | No | -- | -- | 15231747 , 15231747 , 15231747 |
COMT | LITAF | No | -- | -- | 16169070 , 16169070 , 16169070 , 16169070 |
COMT | FBXO6 | No | -- | -- | 22268729 |
COMT | TRIP13 | No | -- | -- | 19060904 , 16189514 , 16189514 , 16189514 , 16189514 |
COMT | RGS2 | Yes | -- | -- | 21900206 , 21900206 , 21900206 |
COMT | VKORC1 | No | -- | -- | 21103663 |
Copyright: Key Lab of Mental Health, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: April 1, 2018