PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Sumner, J. A.,2014 PMID: 24947539
Citation	Sumner, J. A., et al. (2014). "Further support for an association between the memory-related gene WWC1 and posttraumatic stress disorder: results from the Detroit Neighborhood Health Study." Biol Psychiatry 76(11): e25-26.
Phenotype	Lifetime PTSD
Trauma	Various
Study Design	Cross-sectional study
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	598 samples
SNP/Marker Size	1 SNP
Predominant Ethnicity	Black
Population	83% African American
Gender	43% males, 57% females
Age	Mean age=52.3 years, SD=16.1

Detail Info

Genetic result reported by this study

Normal genetic result reported by this study (count: 1)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs10038727	Lifetime PTSD	WWC1	Odds ratio (OR) =0.64 [95% confidence interval (CI)= 0.406-0.997], P-value= 0.049	The WWC1 rs10038727 SNP (coded additively) significantly pre...... The WWC1 rs10038727 SNP (coded additively) significantly predicted lifetime PTSD status, with the minor (A) allele associated with a reduced risk of PTSD. More...	Significant

Gene * Environment result reported by this study (count: 1)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs10038727	Lifetime PTSD	WWC1	Lifetime traumatic load	P-value= 0.65	We did not find evidence of a significant interaction betwee...... We did not find evidence of a significant interaction between rs10038727 genotype and lifetime traumatic load in predicting lifetime PTSD status. More...	Non-significant