Gene Report
| Approved Symbol | FKBP5 |
|---|---|
| Symbol Alias | "FKBP51|FKBP54|PPIase|P54|Ptg-10" |
| Approved Name | FK506 binding protein 5 |
| Previous Name | FK506-binding protein 5 |
| Location | 6p21.31 |
| Position | chr6:35573585-35728583, -1 |
| External Links |
HGNC: 3721 Entrez Gene: 2289 Ensembl: ENSG00000096060 UCSC: uc003okx.2 |
| No. of Association Results | 25 (Positive: 12; Negative: 13; trend: 0) |
| Annotation Type | Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target |
Gene related association results
Normal genetic study related association results (count: 25)
| Reference | Phenotype | Marker | Gene's Category |
|---|---|---|---|
| Watkins, L. E.,2016 | Lifetime PTSD symptoms | rs3800373 ; rs9296158 ; rs1360780 ; rs9470080 | Significant |
| Watkins, L. E.,2016 | Re-experiencing symptoms | rs3800373 ; rs9296158 ; rs1360780 ; rs9470080 | Significant |
| Watkins, L. E.,2016 | Avoidance symptoms (DSM-IV) | rs3800373 ; rs9296158 ; rs1360780 ; rs9470080 | Significant |
| Watkins, L. E.,2016 | Emotional numbing | rs3800373 ; rs9296158 ; rs1360780 ; rs9470080 | Non-significant |
| Watkins, L. E.,2016 | Hyperarousal symptoms | rs3800373 ; rs9296158 ; rs1360780 ; rs9470080 | Significant |
| Watkins, L. E.,2016 | Intrusion symptoms | rs3800373 ; rs9296158 ; rs1360780 ; rs9470080 | Significant |
| Watkins, L. E.,2016 | Avoidance symptoms (DSM-5) | rs3800373 ; rs9296158 ; rs1360780 ; rs9470080 | Non-significant |
| Watkins, L. E.,2016 | Negative alterations in cognitions and mood symptoms | rs3800373 ; rs9296158 ; rs1360780 ; rs9470080 | Non-significant |
| Watkins, L. E.,2016 | Alterations in arousal and reactivity symptoms | rs3800373 ; rs9296158 ; rs1360780 ; rs9470080 | Significant |
| David, A. C.,2012 | Improvement in CAPS PTSD symptoms scores | rs1360780 ; rs3800373 ; rs9296158 ; rs9470080 | Significant |
| Xie, P.,2010 | Lifetime PTSD | rs1360780 ; rs3800373 ; rs9296158 ; rs9470080 | Significant |
| Wilker, S.,2014 | M.I.N.I. suicidality score | rs1360780 | Non-significant |
| David, A. C.,2012 | Memory Performance | rs1360780 ; rs3800373 ; rs9296158 ; rs9470080 | Non-significant |
| Wilker, S.,2014 | PDS avoidance score | rs1360780 | Non-significant |
| Wilker, S.,2014 | PDS hyperarousal score | rs1360780 | Non-significant |
| Wilker, S.,2014 | PDS intrusion score | rs1360780 | Non-significant |
| Wilker, S.,2014 | PDS score | rs1360780 | Non-significant |
| Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | rs1360780 ; rs9296158 ; rs9470080 | Significant |
| Dunn, E. C.,2014 | Post-traumatic stress symptoms (PTS) | rs1360780 ; rs9296158 ; rs9470080 | Non-significant |
| Nievergelt, C. M.,2015 | PTSD | rs9366890 | Significant |
| Kohrt, B. A.,2015 | PTSD (Total PCL-C score) | rs9296158 | Significant |
| Solovieff, N.,2014 | PTSD diagnosis | rs2766581 | Non-significant |
| David, A. C.,2012 | PTSD Diagnostic Status at T2 | rs1360780 ; rs3800373 ; rs9296158 ; rs9470080 | Significant |
| Solovieff, N.,2014 | PTSD severity | rs276651 | Non-significant |
| Binder, E. B.,2008 | PTSD Symptoms (PSS scores) | rs1334894 ; rs1360780 ; rs3800373 ; rs4713916 ; rs737054 ; rs9296158 ; rs9470080 ; rs992105 | Non-significant |
G*E study related association result (count: 1)
Gene functional annotation
Gene related GO terms (count: 11)
Gene related KEGG pathways (count: 0)
Gene related interactors from protein-protein interactions data in PINA v2 (count: 10)