PTSDgene database

SNP Report

Basic Info
Name rs4790904 dbSNP Ensembl
Location 17:66783036 - 66783036(+)
Variant Seq C
Ancestral Allele T
Ref Seq T
Minor Allele Frequence 0.352037
Annotation upstream_gene_variant; intron_variant
Variant Effect upstream_gene_variant(ENST00000385208); intron_variant(ENST00000413366)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000413366)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000413366)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers;Strong transcription;Genic enhancers
No. of Marker's Association Results 9 (Positive: 9; Negative: 0; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 9)
Reference Phenotype Statistical Values Author Comments Marker's Category
de Quervain, D. J.,2012 Avoidance symptoms A allele of rs4790904 with increased avoidance symptoms: P-...... A allele of rs4790904 with increased avoidance symptoms: P-value=0.037. More... The A allele of rs4790904 was associated with increased avoi...... The A allele of rs4790904 was associated with increased avoidance symptoms. More... Significant
de Quervain, D. J.,2012 Hyperarousal symptoms P-value>0.05. P-value>0.05. SNP rs4790904 was not associated with hyperarousal symptoms. SNP rs4790904 was not associated with hyperarousal symptoms. Significant
de Quervain, D. J.,2012 PTSD A allele of rs4790904 with increased risk for PTSD: P-value...... A allele of rs4790904 with increased risk for PTSD: P-value=0.009. More... The A allele of rs4790904 was associated with increased risk...... The A allele of rs4790904 was associated with increased risk for PTSD. More... Significant
Liu, Y.,2013 PTSD category B symptom score Caucasian samples: spearman correlation P-value=0.045; afri...... Caucasian samples: spearman correlation P-value=0.045; african american samples: P-value>0.05 More... SNP rs4790905 was significantly associated with PTSD B sympt...... SNP rs4790905 was significantly associated with PTSD B symptoms in the Caucasian samples including both current PTSD cases and controls, but not the African-American samples. More... Significant
Liu, Y.,2013 PTSD category C symptom score Caucasian samples: spearman correlation P-value=0.016; afri...... Caucasian samples: spearman correlation P-value=0.016; african american samples: P-value>0.05 More... SNP rs4790906 was significantly associated with PTSD C sympt...... SNP rs4790906 was significantly associated with PTSD C symptoms in the Caucasian samples including both current PTSD cases and controls, but not the African-American samples. More... Significant
Liu, Y.,2013 PTSD category D symptom score Caucasian samples: spearman correlation P-value=0.017; afri...... Caucasian samples: spearman correlation P-value=0.017; african american samples: P-value>0.05 More... SNP rs4790907 was significantly associated with PTSD D sympt...... SNP rs4790907 was significantly associated with PTSD D symptoms in the Caucasian samples including both current PTSD cases and controls, but not the African-American samples. More... Significant
Liu, Y.,2013 PTSD diagnosis Caucasian samples: P-value=0.37; african american samples: ...... Caucasian samples: P-value=0.37; african american samples: P-value=0.046 More... We found a significant association between the categorical g...... We found a significant association between the categorical genotype of SNP rs4790904 with current PTSD diagnosis in the African-Americans, but not the Caucasians. More... Significant
de Quervain, D. J.,2012 Reexperiencing symptoms With symptoms of reexperiencing the traumatic event (traumat...... With symptoms of reexperiencing the traumatic event (traumatic memory) in the healthy population: P-value=0.033. More... PRKCA SNP rs4790904 was significantly associated with sympto...... PRKCA SNP rs4790904 was significantly associated with symptoms of reexperiencing the traumatic event (traumatic memory) with the same direction of effect as with memory for negative information in the healthy population. More... Significant
Liu, Y.,2013 Total PTSD symptoms Caucasian samples: spearman correlation P-value=0.02; afric...... Caucasian samples: spearman correlation P-value=0.02; african american samples: P-value>0.05 More... SNP rs4790904 was significantly associated with total PTSD s...... SNP rs4790904 was significantly associated with total PTSD symptoms in the Caucasian samples including both current PTSD cases and controls, but not the African-American samples. More... Significant
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
de Quervain, D. J.,2012 PTSD Sex Sex x SNP interaction: P-value >= 0.7. Sex x SNP interaction: P-value >= 0.7. Sex did not influence the genotype effect on traumatic memor...... Sex did not influence the genotype effect on traumatic memory or PTSD risk. More... Non-significant


SNP related genes (count: 2)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
MIR634 microRNA 634 17q24.2 Mapped by Literature SNP
PRKCA protein kinase C, alpha 17q24.2 10(9/0/1)

SNPs in LD with rs4790904 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
CRHR1 Yes Adipose Subcutaneous cis GTEx