Gene Report

Basic Info

Approved Symbol	UBE2U
Symbol Alias	MGC35130
Approved Name	ubiquitin conjugating enzyme E2U (putative)
Previous Name	ubiquitin-conjugating enzyme E2U (putative)
Location	1p31.3
Position	chr1:64203627-64267368, 1
External Links	HGNC: 28559 Entrez Gene: 148581 Ensembl: ENSG00000177414 UCSC: uc001dbn.1
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	rs138384996	Trend

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs138384996	Non-significant

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0033503	HULC complex	cellular component	IBA	1
GO:0005515	protein binding	molecular function	IPI[19549727\|21516116\|25416956]	169
GO:0016574	histone ubiquitination	biological process	IBA	2
GO:0000790	nuclear chromatin	cellular component	IBA	5
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	biological process	IBA	2
GO:0061630	ubiquitin protein ligase activity	molecular function	IBA	5
GO:0005524	ATP binding	molecular function	IEA	23
GO:0006281	DNA repair	biological process	IBA	8
GO:0000209	protein polyubiquitination	biological process	IBA	4
GO:0005737	cytoplasm	cellular component	IBA	109
GO:0031625	ubiquitin protein ligase binding	molecular function	IBA	6

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04120	Ubiquitin mediated proteolysis	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 50)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
UBE2U	MID2	No	--	--	19690564
UBE2U	BFAR	No	--	--	19690564 , 19690564
UBE2U	TRIM47	No	--	--	19690564 , 19690564
UBE2U	TRIM54	No	--	--	19690564 , 19690564
UBE2U	TRIM74	No	--	--	19549727 , 19549727
UBE2U	RNF166	No	--	--	19690564 , 19690564
UBE2U	CGRRF1	No	--	--	19690564 , 19690564
UBE2U	VPS11	No	--	--	19549727 , 19549727
UBE2U	RNF5	No	--	--	19690564 , 19690564
UBE2U	RNF170	Yes	--	--	19690564 , 19690564
UBE2U	RNF139	No	--	--	19690564 , 19690564
UBE2U	MIB1	No	--	--	19690564 , 19690564
UBE2U	CADPS2	No	--	--	19690564 , 19690564
UBE2U	RNF125	No	--	--	19549727 , 19549727
UBE2U	TRIM65	No	--	--	19690564 , 19690564
UBE2U	ZSWIM2	No	--	--	19690564 , 19690564
UBE2U	SYVN1	No	--	--	19690564 , 19690564
UBE2U	TRIM68	No	--	--	19690564 , 19690564
UBE2U	RNF2	No	--	--	19690564 , 19690564
UBE2U	TRAIP	No	--	--	19690564 , 19690564
UBE2U	RNF26	No	--	--	19690564 , 19690564
UBE2U	RNF10	No	--	--	19549727 , 19549727
UBE2U	MUL1	No	--	--	19690564 , 19690564
UBE2U	TRIM5	No	--	--	19549727 , 19549727
UBE2U	ANAPC11	No	--	--	19690564 , 19690564
UBE2U	PJA1	No	--	--	19690564 , 19690564
UBE2U	TRIM15	No	--	--	19549727 , 19549727
UBE2U	RNF114	No	--	--	19690564 , 19690564
UBE2U	TRIM2	No	--	--	19690564 , 19690564
UBE2U	TRIM35	Yes	--	--	19690564 , 19690564
UBE2U	DTX1	No	--	--	19690564 , 19690564
UBE2U	PCGF1	No	--	--	19690564 , 19690564
UBE2U	MIB2	No	--	--	19690564 , 19690564
UBE2U	RNF17	No	--	--	19690564 , 19690564
UBE2U	RNF144B	No	--	--	19549727 , 19690564 , 19549727 , 19690564
UBE2U	PCGF6	No	--	--	19549727 , 19549727
UBE2U	RNF150	No	--	--	19690564 , 19690564
UBE2U	DZIP3	No	--	--	19549727 , 19549727
UBE2U	RNF181	No	--	--	19690564 , 19690564
UBE2U	RNF11	No	--	--	19690564 , 19690564
UBE2U	RNF41	No	--	--	19690564 , 19690564
UBE2U	BARD1	No	--	--	19690564 , 19690564
UBE2U	KAT6A	No	--	--	19690564 , 19690564
UBE2U	RNF25	No	--	--	19690564 , 19690564
UBE2U	TRIM34	No	--	--	19690564 , 19690564
UBE2U	TRIM46	No	--	--	19549727 , 19549727
UBE2U	RNF14	Yes	--	--	19690564 , 19690564
UBE2U	RBCK1	No	--	--	19549727 , 19549727
UBE2U	TRIM63	No	--	--	19690564
UBE2U	RNF113B	No	--	--	19690564