Gene Report

Basic Info

Approved Symbol	CRHR1
Previous Symbol	CRHR
Symbol Alias	"CRF-R\|CRF1"
Approved Name	corticotropin releasing hormone receptor 1
Name Alias	corticotropin-releasing factor receptor
Location	17q21.31
Position	chr17:45784280-45835828, 1
External Links	HGNC: 2357 Entrez Gene: 1394 Ensembl: ENSG00000120088 UCSC: uc002ijm.3
No. of Association Results	12 (Positive: 6; Negative: 6; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 12)

Reference	Phenotype	Marker	Gene's Category
Amstadter, A. B.,2011	Acute symptoms of PTSD	rs12944712	Significant
Amstadter, A. B.,2011	Acute UCLA PTSD-RI score	rs12936181 ; rs12944712 ; rs17690314 ; rs17763104 ; rs17763658 ; rs2424942 ; rs4074461 ; rs4458044	Significant
Amstadter, A. B.,2011	Decline in PTSD symptoms	rs12944712	Significant
Dunn, E. C.,2014	Post Traumatic Growth (PTG)	rs12944712	Non-significant
White, S.,2013	Post-hurricane PTSD diagnosis	rs12938031 ; rs4792887	Significant
White, S.,2013	Post-hurricane PTSD symptoms	rs110402 ; rs12938031 ; rs16940686 ; rs171441 ; rs173365 ; rs17689966 ; rs242924 ; rs242936 ; rs242939 ; rs2664008 ; rs4792887 ; rs7209436	Significant
Davydow, D. S.,2014	Post-ICU PTSD	rs1876831	Non-significant
Dunn, E. C.,2014	Post-traumatic stress symptoms (PTS)	rs12944712	Non-significant
Nievergelt, C. M.,2015	PTSD	rs116897693	Significant
Solovieff, N.,2014	PTSD diagnosis	rs242941	Non-significant
Solovieff, N.,2014	PTSD severity	rs242941	Non-significant
Binder, E. B.,2008	PTSD symptom severity	rs110402 ; rs242924 ; rs7209436	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Dunn, E. C.,2014	Post Traumatic Growth (PTG)	Hurricane exposure	rs12944712 ; rs116897693 ; rs110402 ; rs242924 ; rs7209436	Non-significant

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:2000852	regulation of corticosterone secretion	biological process	ISS	1
GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological process	IMP[23863939]	1
GO:0071376	cellular response to corticotropin-releasing hormone stimulus	biological process	IDA[18292205]	2
GO:0051458	corticotropin secretion	biological process	ISS	1
GO:0016021	integral component of membrane	cellular component	IDA[23863939]	56
GO:0007565	female pregnancy	biological process	NAS[7585095]	9
GO:1901386	negative regulation of voltage-gated calcium channel activity	biological process	IDA[18292205]	4
GO:0006955	immune response	biological process	TAS[7692441]	6
GO:0005515	protein binding	molecular function	IPI[18801728]	169
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0007567	parturition	biological process	TAS[10598591]	1
GO:0007166	cell surface receptor signaling pathway	biological process	IEA	16
GO:0010579	positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway	biological process	IDA[18292205]	2
GO:0007190	activation of adenylate cyclase activity	biological process	TAS[10598591]	6
GO:0015056	corticotrophin-releasing factor receptor activity	molecular function	IDA[18292205]	2
GO:0005768	endosome	cellular component	IEA	5
GO:0005887	integral component of plasma membrane	cellular component	TAS[10598591]	36
GO:0031226	intrinsic component of plasma membrane	cellular component	IDA[18292205]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in PTSDgene
hsa04730	Long-term depression	4
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 7)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CRHR1	UCN3	No	--	--	11416224
CRHR1	SRPK1	No	--	--	23602568 , 23602568
CRHR1	CALM1	No	--	--	15670850 , 15670850 , 15670850 , 15670850
CRHR1	GNAS	No	--	--	10598591 , 10598591
CRHR1	GNAQ	No	--	--	10598591 , 10598591
CRHR1	GNAI1	No	--	--	10598591 , 10598591
CRHR1	UCN	No	--	--	9423932 , 8612563 , 8612563