
Gene Report
Approved Symbol | CRHR1 |
---|---|
Previous Symbol | CRHR |
Symbol Alias | "CRF-R|CRF1" |
Approved Name | corticotropin releasing hormone receptor 1 |
Name Alias | corticotropin-releasing factor receptor |
Location | 17q21.31 |
Position | chr17:45784280-45835828, 1 |
External Links |
HGNC: 2357 Entrez Gene: 1394 Ensembl: ENSG00000120088 UCSC: uc002ijm.3 |
No. of Association Results | 12 (Positive: 6; Negative: 6; trend: 0) |
Annotation Type | Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target |
Reference | Phenotype | Marker | Gene's Category |
---|---|---|---|
Amstadter, A. B.,2011 | Acute symptoms of PTSD | rs12944712 | Significant |
Amstadter, A. B.,2011 | Acute UCLA PTSD-RI score | rs12936181 ; rs12944712 ; rs17690314 ; rs17763104 ; rs17763658 ; rs2424942 ; rs4074461 ; rs4458044 | Significant |
Amstadter, A. B.,2011 | Decline in PTSD symptoms | rs12944712 | Significant |
Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | rs12944712 | Non-significant |
White, S.,2013 | Post-hurricane PTSD diagnosis | rs12938031 ; rs4792887 | Significant |
White, S.,2013 | Post-hurricane PTSD symptoms | rs110402 ; rs12938031 ; rs16940686 ; rs171441 ; rs173365 ; rs17689966 ; rs242924 ; rs242936 ; rs242939 ; rs2664008 ; rs4792887 ; rs7209436 | Significant |
Davydow, D. S.,2014 | Post-ICU PTSD | rs1876831 | Non-significant |
Dunn, E. C.,2014 | Post-traumatic stress symptoms (PTS) | rs12944712 | Non-significant |
Nievergelt, C. M.,2015 | PTSD | rs116897693 | Significant |
Solovieff, N.,2014 | PTSD diagnosis | rs242941 | Non-significant |
Solovieff, N.,2014 | PTSD severity | rs242941 | Non-significant |
Binder, E. B.,2008 | PTSD symptom severity | rs110402 ; rs242924 ; rs7209436 | Non-significant |
Reference | Phenotype | Environment | Marker | Gene's Category |
---|---|---|---|---|
Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | Hurricane exposure | rs12944712 ; rs116897693 ; rs110402 ; rs242924 ; rs7209436 | Non-significant |
ID | Name | No. of Genes in PTSDgene |
---|---|---|
hsa04730 | Long-term depression | 4 |
hsa04080 | Neuroactive ligand-receptor interaction | 22 |
Gene | Interactor | Interactor in PTSDgene? | Experiment Method | Interaction Type | PMID |
---|---|---|---|---|---|
CRHR1 | GNAS | No | -- | -- | 10598591 , 10598591 |
CRHR1 | CALM1 | No | -- | -- | 15670850 , 15670850 , 15670850 , 15670850 |
CRHR1 | GNAI1 | No | -- | -- | 10598591 , 10598591 |
CRHR1 | GNAQ | No | -- | -- | 10598591 , 10598591 |
CRHR1 | SRPK1 | No | -- | -- | 23602568 , 23602568 |
CRHR1 | UCN3 | No | -- | -- | 11416224 |
CRHR1 | UCN | No | -- | -- | 9423932 , 8612563 , 8612563 |
Copyright: Key Lab of Mental Health, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: April 1, 2018