Study Report
Study Information
Basic Info
| Reference |
Liu, Y.,2015 PMID: 25793742
|
| Citation |
Liu, Y., et al. (2015). "An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans." PLoS One 10(3): e0119998. |
| Phenotype |
Current diagnosis of PTSD, PTSD status |
| Trauma |
Combat |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study, Gene-environment interaction study |
| Sample Size |
550 NHB participants and 555 NHW participants |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Black, Caucasian |
| Population |
Non-Hispanic Black (NHB) or Non-Hispanic White (NHW) |
| Gender |
550 NHB participants (77.8% males) and 555 NHW participants (90.6% males) |
| Age |
NHB cases: mean age=38.37 years, SD=9.80; NHB controls: mean age=38.67, SD=9.33; NHW cases: mean age=34.49 years, SD=9.18; NHW controls: mean age=36.76 years, SD=10.99. |
Detail Info
| Sample Diagnosis |
DSM-IV |
| Related Diagnostic Tools |
Combat Exposure Scale (CES), Structured Clinical Interview for DSM-IV Disorders (SCID), the Clinician-Administered PTSD Scale for DSM-IV (CAPS), Davidson Trauma Scale (DTS), The Traumatic Life Events Questionnaire (TLEQ) |
| Sample Status |
Participants were recruited through fliers, advertisements and invitational letters to participate in one of several studies that assessed PTSD and collected a genetic sample, including the Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC) Registry study and several independent trauma research studies conducted through the Durham VA Medical Center. |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
Within the NHB sample, a significant additive effect was observed for 5-HTTLPR (OR=1.502, P-value=.0025), such that the odds of having a current diagnosis of PTSD increased by 1.502 for each additional S' allele. No evidence for an association between 5-HTTLPR and PTSD was observed in the NHW sample. In addition, no evidence for combat x 5-HTTLPR effects were observed in either sample. The present study suggests that there may be an association between 5-HTTLPR genotype and PTSD diagnosis among NHB veterans; however, no evidence for the hypothesized 5-HTTLPR x combat interaction was found. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
Current diagnosis of PTSD |
SLC6A4 |
Among NHB veterans, OR=1.502, P-value=.0025. Among NHW veterans: P-value= .4671. |
A significant additive effect was observed for 5-HTTLPR amon......
A significant additive effect was observed for 5-HTTLPR among NHB veterans, such that the odds of having a current diagnosis of PTSD increased by 1.502 for each additional S' allele. As can be seen in Fig. 1, the rate of PTSD was higher among S' homozygotes (87/160 or 54.38%) compared with heterozygotes (108/235 or 45.96%) and L' homozygotes (59/155 or 38.06%). No main effect was observed for 5-HTTLPR among NHW veterans. As can be seen in Fig. 1, the rate of PTSD among S' homozygotes (71/149 or 47.65%), heterozygotes (123/258 or 47.67%), and L' homozygotes (69/148 or 46.62%) was nearly identical.
More...
|
Significant |
Gene * Environment result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Environment |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
PTSD status |
SLC6A4 |
Combat exposure |
Logistic regression model 5-HTTLPR x combat exposure interaction term, on the NHB sample: P-value=.65; on the NHW sample: P-value=.51. |
A second logistic regression model was conducted on the NHB ......
A second logistic regression model was conducted on the NHB sample to test for potential 5-HTTLPR x combat exposure effects on PTSD status. The results from this model were highly similar to the first. 5-HTTLPR, civilian trauma, combat trauma, and PC1 all continued to have significant main effects on PTSD; however, no other variable in the model, including the 5-HTTLPR x combat exposure interaction term, was significant. Similar results were obtained from the second logistic regression model that tested for 5-HTTLPR x combat exposure effects on PTSD among NBW sample.
More...
|
Non-significant |
