Gene Report

Basic Info

Approved Symbol	LRPAP1
Previous Symbol	A2MRAP
Symbol Alias	HBP44
Approved Name	LDL receptor related protein associated protein 1
Previous Name	"low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)\|low density lipoprotein receptor-related protein associated protein 1"
Location	4p16.3
Position	chr4:3506376-3532559, -1
External Links	HGNC: 6701 Entrez Gene: 4043 Ensembl: ENSG00000163956 UCSC: uc003ghh.4
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	rs62275374	Trend

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs62275374	Significant

Gene functional annotation

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0004873	asialoglycoprotein receptor activity	molecular function	TAS[2229028]	1
GO:0031982	vesicle	cellular component	IEA	7
GO:0050750	low-density lipoprotein particle receptor binding	molecular function	IDA[16263759]	5
GO:0016192	vesicle-mediated transport	biological process	TAS[8654360]	1
GO:0006898	receptor-mediated endocytosis	biological process	TAS[2229028]	9
GO:1900222	negative regulation of beta-amyloid clearance	biological process	IGI[19098903]	1
GO:0032091	negative regulation of protein binding	biological process	IDA[8083232]	1
GO:0070326	very-low-density lipoprotein particle receptor binding	molecular function	IPI[8083232]	2
GO:0005515	protein binding	molecular function	IPI[8083232]	169
GO:0005783	endoplasmic reticulum	cellular component	IDA	20
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	biological process	IDA[8083232]	3
GO:0051082	unfolded protein binding	molecular function	TAS[8654360]	1
GO:0048019	receptor antagonist activity	molecular function	IDA[8083232]	1
GO:0006457	protein folding	biological process	TAS[8654360]	3
GO:0016021	integral component of membrane	cellular component	TAS[1712782]	56
GO:0048237	rough endoplasmic reticulum lumen	cellular component	IEA	1
GO:0009986	cell surface	cellular component	IEA	21
GO:1900116	extracellular negative regulation of signal transduction	biological process	IDA[8083232]	1
GO:0035473	lipase binding	molecular function	IEA	3
GO:0005886	plasma membrane	cellular component	IDA[16263759]	99
GO:0005576	extracellular region	cellular component	IDA[8083232]	31
GO:0008201	heparin binding	molecular function	IEA	4

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 18)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
LRPAP1	LRP1B	No	--	--	11384978
LRPAP1	SORT1	No	--	association	10085125 , 10085125 , 9013611 , 9013611 , 19122660
LRPAP1	POLA2	No	--	--	16169070 , 16169070 , 16169070 , 16169070 , 16169070
LRPAP1	VLDLR	No	--	--	8083232 , 8083232 , 8083232 , 10571241 , 8083232 , 12899622 , 7592875
LRPAP1	ETV7	No	--	--	21988832 , 21988832
LRPAP1	RTN4	No	--	--	16169070 , 16169070 , 16169070 , 16169070 , 16169070
LRPAP1	SUMO2	No	--	--	17000644 , 17000644
LRPAP1	SMAD2	No	--	--	20195357
LRPAP1	LRP8	No	--	--	12899622 , 12899622
LRPAP1	LRP2	No	--	--	7512726 , 11912251 , 7512726
LRPAP1	RANBP2	No	--	--	20936779 , 20936779
LRPAP1	SUMO1	No	--	--	15576338
LRPAP1	RALGDS	No	--	--	10783161
LRPAP1	MTOR	No	--	--	16798736
LRPAP1	LRP1	No	--	--	1374383 , 10747918
LRPAP1	NRF1	No	--	colocalization	24250222
LRPAP1	SORL1	No	biochemical	association	8940146 , 11557679 , 11557679
LRPAP1	EIF4EBP1	No	--	--	16798736