SNP Report
Basic Info
| Name | rs1081105 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 19:44909698 - 44909698(+) | ||
| Variant Seq | C | ||
| Ancestral Allele | A | ||
| Ref Seq | A | ||
| Minor Allele Frequence | 0.0301518 | ||
| Annotation | downstream_gene_variant; non_coding_transcript_exon_variant; upstream_gene_variant; non_coding_transcript_variant | ||
| Variant Effect | downstream_gene_variant(ENST00000485628, ENST00000446996, ENST00000434152, ENST00000425718, ENST00000252486); non_coding_transcript_exon_variant(ENST00000623895); upstream_gene_variant(ENST00000588750, ENST00000588802, ENST00000592535); non_coding_transcript_variant(ENST00000623895) | ||
| SIFT Annotation | deleterious_-_low_confidence; tolerated_-_low_confidence; tolerated | ||
| SIFT Variant Effect | deleterious_-_low_confidence(ENST00000592885); tolerated_-_low_confidence(ENST00000589078, ENST00000586638, ENST00000590334); tolerated(ENST00000592535, ENST00000588802, ENST00000588750) | ||
| PolyPhen Annotation | unknown; probably_damaging | ||
| PolyPhen Variant Effect | unknown(ENST00000589781, ENST00000592176); probably_damaging(ENST00000589078, ENST00000586638, ENST00000592535, ENST00000590334, ENST00000588802, ENST00000592885, ENST00000588750) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | TF binding region;Chromatin interactive region | ||
| Chromatin State | Weak transcription;Strong transcription;Enhancers;Active TSS;Genic enhancers | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 1; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | In 2179 MRS subjects of European descent: P-value=0.05. In 2179 MRS subjects of European descent: P-value=0.05. | P-value is suggestive significant (P-value=0.05). P-value is suggestive significant (P-value=0.05). | Non-significant |
G*E study related association result (count: 1)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | Childhood trauma | In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value=0.036. More... | It showed a significant interaction effect with childhood tr...... It showed a significant interaction effect with childhood trauma on PTSD. More... | Significant |
SNP related genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| APOE | apolipoprotein E | 19q13.31 | 6(2/4/0) |
| APOC1 | apolipoprotein C-I | 19q13.2 | Mapped by Literature SNP, Mapped by LD-proxy |
| CLPTM1 | cleft lip and palate associated transmembrane protein 1 | 19q13.3 | rSNP target |
SNPs in LD with rs1081105 (count: 0)
SNP related eQTL (count: 1)