SNP Report

Basic Info

Name	rs992105 dbSNP Ensembl
Location	6:35587406 - 35587406(+)
Variant Seq	A
Ancestral Allele	A
Ref Seq	C
Minor Allele Frequence	0.182708
Annotation	intron_variant
Variant Effect	intron_variant(ENST00000536438, ENST00000539068, ENST00000357266, ENST00000542713)
SIFT Annotation	tolerated
SIFT Variant Effect	tolerated(ENST00000539068, ENST00000542713, ENST00000536438, ENST00000357266)
PolyPhen Annotation	benign
PolyPhen Variant Effect	benign(ENST00000539068, ENST00000542713, ENST00000536438, ENST00000357266)
rSNP?	Yes Link in rVarBase
Related Regulatory Elements	Chromatin interactive region
Chromatin State	Strong transcription;Weak transcription;Genic enhancers;Enhancers;Flanking Active TSS
No. of Marker's Association Results	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature

SNP related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Binder, E. B.,2008	PTSD Symptoms (PSS scores)	No available detail information. No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Statistical Values	Author Comments	Marker's Category
Binder, E. B.,2008	PTSD Symptoms (PSS scores)	Child abuse	No available detail information. No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Association Results (Positive/Negative/Trend)
FKBP5	FK506 binding protein 5	6p21.31	25(12/13/0)

SNPs in LD with rs992105 (count: 8)

The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r²<=0.8.


rs_ID	Annotation	No. of Association Results(Positive/Negative/Trend)	r²[population]
rs9366890	intron_variant(ENST00000542713, ENST00000539068, ENST00000357266, ENST00000536438)	1(1/0/0)	0.8949[AFR]

rs_ID	Literature-origin SNPs with LD	Annotation	r²[population]
rs10947558	rs992105	downstream_gene_variant	0.8222[AMR]
rs4713897	rs992105	downstream_gene_variant	0.8000[AMR]
rs3800374	rs9366890 rs992105	downstream_gene_variant	0.9107[AFR]; 0.8958[AMR]
rs4401662	rs9366890 rs992105	intron_variant	0.8508[AFR]
rs6926133	rs9366890 rs992105	downstream_gene_variant; intron_variant	0.8655[AFR]
rs10807152	rs9366890 rs992105	downstream_gene_variant; intron_variant	0.8802[AFR]
rs7771727	rs9366890 rs992105	intron_variant	0.8701[AMR]

SNP related eQTL (count: 1)

Gene Symbol	Gene Existed in PTSDgene?	Tissue	Trans/Cis	Source
CRHR1	Yes	Adipose Subcutaneous	cis	GTEx