Gene Report

Basic Info

Approved Symbol	TPH2
Symbol Alias	"NTPH\|FLJ37295"
Approved Name	tryptophan hydroxylase 2
Name Alias	tryptophan 5-monooxygenase
Location	12q15
Position	chr12:71938846-72186618, 1
External Links	HGNC: 20692 Entrez Gene: 121278 Ensembl: ENSG00000139287 UCSC: uc009zrw.1
No. of Association Results	10 (Positive: 3; Negative: 7; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 10)

Reference	Phenotype	Marker	Gene's Category
Cao, C.,2014	Anxious arousal symptoms	rs11178997	Non-significant
Cao, C.,2014	Avoidance symptoms	rs11178997	Significant
Cao, C.,2014	Dysphoric arousal symptoms	rs11178997	Non-significant
Cao, C.,2014	Emotional numbing symptoms	rs11178997	Non-significant
Nievergelt, C. M.,2015	PTSD	rs183063707	Significant
Solovieff, N.,2014	PTSD diagnosis	rs17110747	Non-significant
Solovieff, N.,2014	PTSD severity	rs7300641	Non-significant
Cao, C.,2014	PTSD symptoms	rs11178997	Non-significant
Goenjian, A. K.,2012	PTSD-RI (PTSD symptoms)	rs11178997 ; rs1386494 ; rs17110747 ; rs2129575 ; rs4290270 ; rs4570625	Significant
Cao, C.,2014	Reexperiencing symptoms	rs11178997	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs183063707	Non-significant

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0004510	tryptophan 5-monooxygenase activity	molecular function	IEA	2
GO:0014823	response to activity	biological process	IEA	5
GO:0005829	cytosol	cellular component	TAS	78
GO:0005506	iron ion binding	molecular function	IEA	5
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0046219	indolalkylamine biosynthetic process	biological process	TAS	2
GO:0043005	neuron projection	cellular component	IEA	17
GO:0042427	serotonin biosynthetic process	biological process	IEA	2
GO:0009072	aromatic amino acid family metabolic process	biological process	IEA	2
GO:0031667	response to nutrient levels	biological process	IEA	3
GO:0051384	response to glucocorticoid	biological process	IEA	3
GO:0043627	response to estrogen	biological process	IEA	5
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0071285	cellular response to lithium ion	biological process	IEA	1
GO:0051592	response to calcium ion	biological process	IEA	4
GO:0016597	amino acid binding	molecular function	IEA	3
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	11
GO:0007623	circadian rhythm	biological process	IEA	5

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa00380	Tryptophan metabolism	6

Gene related interactors from protein-protein interactions data in PINA v2 (count: 0)