Gene Report

Basic Info

Approved Symbol	UBE2E3
Symbol Alias	UbcH9
Approved Name	ubiquitin conjugating enzyme E2E 3
Previous Name	"ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5)\|ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)\|ubiquitin-conjugating enzyme E2E 3"
Location	2q31.3
Position	chr2:180967248-181076585, 1
External Links	HGNC: 12479 Entrez Gene: 10477 Ensembl: ENSG00000170035 UCSC: uc032oln.1
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	rs187093517	Trend

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs187093517	Non-significant

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0005524	ATP binding	molecular function	IEA	23
GO:0004842	ubiquitin-protein transferase activity	molecular function	IDA[20061386]	5
GO:0070534	protein K63-linked ubiquitination	biological process	IDA[20061386]	1
GO:0070936	protein K48-linked ubiquitination	biological process	IDA[20061386]	1
GO:0005737	cytoplasm	cellular component	IEA	109
GO:0005515	protein binding	molecular function	IPI[14667819\|19549727\|25416956]	169
GO:0070979	protein K11-linked ubiquitination	biological process	IDA[20061386]	1
GO:0005634	nucleus	cellular component	IEA	81
GO:0061631	ubiquitin conjugating enzyme activity	molecular function	IEA	1
GO:0040008	regulation of growth	biological process	IEA	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04120	Ubiquitin mediated proteolysis	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 35)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
UBE2E3	ARID3A	No	--	--	15017387 , 15017387 , 15017387
UBE2E3	RNF115	No	--	--	19690564 , 19690564
UBE2E3	DDA1	No	--	colocalization	17452440 , 17452440
UBE2E3	RNF25	No	--	--	19549727 , 19690564 , 19690564 , 19549727
UBE2E3	CHFR	No	--	--	19549727 , 19549727
UBE2E3	RNF5	No	--	--	14667819 , 14667819 , 14667819 , 14667819 , 14667819 , 19549727 , 14667819 , 19549727 , 14667819 , 15545318 , 14667819
UBE2E3	RPS27A	No	--	--	19549727
UBE2E3	RNF150	No	--	--	19690564 , 19690564
UBE2E3	AUP1	No	--	--	19549727
UBE2E3	RNF2	No	--	--	19549727 , 19549727
UBE2E3	RNF114	No	--	--	19549727 , 19549727
UBE2E3	STUB1	No	--	--	21518764
UBE2E3	RNF166	No	--	--	19549727 , 19549727
UBE2E3	RNF167	No	--	--	19690564 , 19690564 , 23414517
UBE2E3	TRIM39	No	--	--	19549727 , 19549727
UBE2E3	TRIM45	No	--	--	21143188
UBE2E3	MUL1	No	--	--	19690564 , 19690564
UBE2E3	IPO11	No	--	--	11809816 , 15545318 , 15545318 , 15545318
UBE2E3	TBL1XR1	No	--	--	18202150
UBE2E3	RNF14	Yes	--	--	11322894 , 19549727 , 11322894 , 19549727
UBE2E3	MID2	No	--	--	21143188 , 21143188
UBE2E3	SAE1	No	--	--	10187858
UBE2E3	KLHDC5	No	--	--	19256485
UBE2E3	HERC5	No	--	--	19549727
UBE2E3	TRIM2	No	--	--	19549727 , 19549727
UBE2E3	BARD1	No	--	--	21965653
UBE2E3	SIRT5	No	--	--	22318606
UBE2E3	RNF185	No	--	--	19549727 , 19549727
UBE2E3	RNF11	No	--	--	19549727 , 19549727
UBE2E3	ZNRF4	No	--	--	19690564 , 19690564
UBE2E3	RNF181	No	--	--	19690564 , 19690564
UBE2E3	ITCH	No	--	--	22496338
UBE2E3	RMND5B	No	--	--	19690564 , 19690564
UBE2E3	NEDD4L	No	--	--	22496338
UBE2E3	UBC	No	--	--	19549727