PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Almli, L. M.,2014 PMID: 24576688
Citation	Almli, L. M., et al. (2014). "Follow-up and extension of a prior genome-wide association study of posttraumatic stress disorder: gene x environment associations and structural magnetic resonance imaging in a highly traumatized African-American civilian population." Biol Psychiatry 76(4): e3-4.
Phenotype	PTSD symptoms (mPSS)
Trauma	Highly traumatized (no detail information)
Study Design	Case-control
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	3215 subjects
SNP/Marker Size	6 SNPs
Predominant Ethnicity	Black
Population	Primarily African American
Gender	primarily female
Age	Not mentioned

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	PTSD symptom scale (mPSS), Childhood Trauma Questionnaire, Beck Depression Inventory.
Sample Status	Our sample consisted of study participants from Grady Memorial Hospital (Atlanta, Georgia) as part of the Grady Trauma Project.
Controls Exposed	NA
Replication Size	None
Result Summary	In summary, we found a significant effect of rs406001 (and other SNPs in linkage disequilibrium) interacting with childhood trauma exposure in a large AA cohort. These data suggest that examining trauma exposure in combination with genetic risk might allow more robust integration across population cohorts, because the original study found no main effect in AA subjects. The rs406001 SNP is intergenic with no known function; however, the closest gene is COBL, which might be related to actin polymerization and neuronal development and function. Our brain imaging findings indicate that risk allele carriers demonstrate alterations in white matter integrity in brain regions associated with emotion processing; in particular, the uncinate fasciculus serves as a primary connection between the amygdala and ventral aspects of the prefrontal cortex, which is thought to play a role in extinction of learned fear (9,10). Thus, it is possible that risk allele carriers are more vulnerable to the development of anxious psychopathology via decrements in these white matter pathways. These data serve as a partial replication and extension of the first large GWAS for PTSD and suggest a putative white matter intermediate phenotype that might underlie PTSD risk.
Potential Biomarker	These data suggest a putative white matter intermediate phenotype that might underlie PTSD risk.

Genetic result reported by this study

Normal genetic result reported by this study (count: 6)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs450378	PTSD symptoms (mPSS)	COBL	Linear regression, main effect P-value=0.97	They did not replicate as main effects in associations with ...... They did not replicate as main effects in associations with PTSD symptoms in this study. More...	Non-significant
rs406001	PTSD symptoms (mPSS)	COBL	Linear regression, main effect P-value=0.34	They did not replicate as main effects in associations with ...... They did not replicate as main effects in associations with PTSD symptoms in this study. More...	Non-significant
rs382903	PTSD symptoms (mPSS)	COBL	Linear regression, main effect P-value=0.17	They did not replicate as main effects in associations with ...... They did not replicate as main effects in associations with PTSD symptoms in this study. More...	Non-significant
rs1503292	PTSD symptoms (mPSS)	TLL1	Linear regression, main effect P-value=0.94	They did not replicate as main effects in associations with ...... They did not replicate as main effects in associations with PTSD symptoms in this study. More...	Non-significant
rs7691872	PTSD symptoms (mPSS)	TLL1	Linear regression, main effect P-value=0.26	They did not replicate as main effects in associations with ...... They did not replicate as main effects in associations with PTSD symptoms in this study. More...	Non-significant
rs6812849	PTSD symptoms (mPSS)	TLL1	Linear regression, main effect P-value=0.80	They did not replicate as main effects in associations with ...... They did not replicate as main effects in associations with PTSD symptoms in this study. More...	Non-significant

Gene * Environment result reported by this study (count: 6)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs7691872	PTSD symptoms (mPSS)	TLL1	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0.11, GxE P-value(adjusted with robust standard errors with R package geepack)=0.13.	We haven't found a significant genotype and environment inte...... We haven't found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Non-significant
rs450378	PTSD symptoms (mPSS)	COBL	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0.008, GxE P-value(adjusted with robust standard errors with R package geepack)=0.02.	We found a significant genotype and environment interaction ...... We found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Significant
rs6812849	PTSD symptoms (mPSS)	TLL1	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0.45, GxE P-value(adjusted with robust standard errors with R package geepack)=0.45.	We haven't found a significant genotype and environment inte...... We haven't found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Non-significant
rs382903	PTSD symptoms (mPSS)	COBL	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0.0003, GxE P-value(adjusted with robust standard errors with R package geepack)=0.001.	We found a significant genotype and environment interaction ...... We found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Significant
rs406001	PTSD symptoms (mPSS)	COBL	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0.0006, GxE P-value(adjusted with robust standard errors with R package geepack)=0.002.	We found a significant genotype and environment interaction ...... We found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Significant
rs1503292	PTSD symptoms (mPSS)	TLL1	Childhood trauma	Linear regression, GxE P-value(standard regression model)=0.39, GxE P-value(adjusted with robust standard errors with R package geepack)=0.44.	We haven't found a significant genotype and environment inte...... We haven't found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More...	Non-significant