PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Clark, R., et al. (2013). "Predicting post-traumatic stress disorder in veterans: interaction of traumatic load with COMT gene variation." J Psychiatr Res 47(12): 1849-1856.
Phenotype PTSD symptoms (combined scores for severity and frequency)
Trauma Iraq War (military veterans)
Study Design Longitudinal design
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 236 participants
SNP/Marker Size 1 SNP
Predominant Ethnicity Caucasian
Population White
Gender all male
Age Met/Met (n=63): mean age=31.51, SD=9.93; Val/Met (n=131): mean age=30.03, SD=8.51; Val/Val (n=42): mean age=29.94, SD=8.56.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs4680 PTSD symptoms (combined scores for severity and frequency) COMT Met/Met(N=63), Val/Met(N=131), Val/Val(N=42),F-test=0.70, P-value=0.49. Regression 1 (trauma and COMT variation), Block 1 main effects: Val/Met genotype, Wald X2=2.79, df=2, P-value=0.248; Val/Val, b=0.349, SE=0.212, Wald X2=0.81, df=1, P-value=0.775; Met/Met, b=0.048, SE=0.167, Wald X2=2.69, df=1, P-value=0.101. Block 2 main effects with interactions: Val/Met genotype, Wald X2=5.97, df=2, P-value=0.051; Val/Val, b=-0.658, SE=0.500, Wald X2=1.77, df=1, P-value=0.184; Met/Met, b=-0.935, SE=0.402, Wald X2=5.42, df=1, P-value=0.020. Regression 2 ( interaction of trauma and COMT variation with pre-trauma personality factors), Block 1 main effects: Val/Met polymorphism, Wald X2=2.99, df=2, P-value=0.224; Val/Val, b=0.371, SE=0.216, Wald X2=2.96, df=1, P-value=0.085; Met/Met, b=0.078, SE=0.167, Wald X2=0.22, df=1, P-value=0.643. Block 2 main effects with interactions: Val/Met genotype, Wald X2=6.81, df=2, P-value=0.033; Val/Val, b=-0.815, SE=0.512, Wald X2=2.54, df=1, P-value=0.111; Met/Met, b=-0.951, SE=0.394, Wald X2=5.81, df=1, P-value=0.016. Regression 3 ( interaction of trauma and COMT variation considering time of trauma), Block 1 main effects: Val/Met polymorphism, Wald X2=2.97, df=2, P-value=0.226; Val/Val, b=0.371, SE=0.216, Wald X2=2.95, df=1, P-value=0.086; Met/Met, b=0.085, SE=0.168, Wald X2=0.441, df=1, P-value=0.615. Block 2 main effects with interactions: Val/Met genotype, Wald X2=6.88, df=2, P-value=0.032; Val/Val, b=-0.815, SE=0.513, Wald X2=2.53, df=1, P-value=0.112; Met/Met, b=-0.940, SE=0.386, Wald X2=5.94, df=1, P-value=0.015. The main effect of COMT genotype didn't predict PTSD symptom...... The main effect of COMT genotype didn't predict PTSD symptoms. More... Non-significant

Gene * Environment result reported by this study (count: 2)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
rs4680 PTSD symptoms (combined scores for severity and frequency) COMT Traumatic load (it was divided into trauma experienced prior to deployment (named predeployment trauma) and trauma experienced during deployment (named deployment-based trauma)) Regression 3 (interaction of trauma and COMT variation considering time of trauma), Block 2 main effects with interaction, controlling for internalizing and externalizing, Val/Met genotype and predeployment trauma interaction: Wald X2=5.60, df=2, P-value=0.061; Val/Val genotype and predeployment trauma interaction: b=0.170, SE=0.136, Wald X2=1.56, df=1, P-value=0.212; Met/Met genotype and predeployment trauma interaction: b=0.186, SE=0.082, Wald X2=5.19, df=1, P-value=0.023; Val/Met genotype and deployment-based trauma interaction: Wald X2=3.09, df=2, P-value=0.213; Val/Val genotype and deployment-based trauma interaction: b=0.128, SE=0.087, Wald X2=2.17, df=1, P-value=0.141; Met/Met genotype and deployment-based trauma interaction: b=0.077, SE=0.056, Wald X2=1.86, df=1, P-value=0.173; The interaction between trauma load and COMT was a significa...... The interaction between trauma load and COMT was a significant predictor of PTSD symptoms. Those with the heterozygous genotype (Val/Met) showed fewer symptoms associated with trauma exposure compared to those with either homozygous genotype. This interaction remained significant after controlling for other risk factors for PTSD, including personality dimensions of Internalizing and Externalizing. More... Significant
rs4680 PTSD symptoms (combined scores for severity and frequency) COMT PTE (potentially traumatizing events) Regression 1 (trauma and COMT variation), Block 2 main effects with interactions: PTE and Val/Met genotype interaction, Wald X2=10.08, df=2, P-value=0.007; PTE and Val/Val interaction, b=0.118, SE=0.052, Wald X2=5.08, df=1, P-value=0.024; PTE and Met/Met interaction, b=0.107, SE=0.040, Wald X2=7.18, df=1, P-value=0.007. Regression 2 (interaction of trauma and COMT variation with pre-trauma personality factors), controlling for internalizing and externalizing, Block 2 main effects with interactions: PTE and Val/Met genotype interaction, Wald X2=11.74, df=2, P-value=0.003; PTE and Val/Val interaction, b=0.141, SE=0.055, Wald X2=6.65, df=1, P-value=0.010; PTE and Met/Met interaction, b=0.113, SE=0.040, Wald X2=8.17, df=1, P-value=0.004. Block 2 of that regression 1 tests the interaction between t...... Block 2 of that regression 1 tests the interaction between trauma and genotype. A significant gene-environment interaction indicated that the three COMT genotypes had different patterns of response to trauma. Regression 2 shows that the interaction between genotype and level of lifetime trauma remained significant when controlling for Internalizing and Externalizing. More... Significant