Gene Report

Basic Info

Approved Symbol	CYP11B1
Previous Symbol	CYP11B
Symbol Alias	"P450C11\|FHI\|CPN1"
Approved Name	cytochrome P450 family 11 subfamily B member 1
Previous Name	"cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 1\|cytochrome P450, family 11, subfamily B, polypeptide 1"
Name Alias	steroid 11-beta-monooxygenase
Location	8q21-q22
Position	chr8:142872356-142879846, -1
External Links	HGNC: 2591 Entrez Gene: 1584 Ensembl: ENSG00000160882 UCSC: uc003yxi.3
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	rs142570922	Trend

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs142570922	Significant

Gene functional annotation

Gene related GO terms (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0008202	steroid metabolic process	biological process	TAS	2
GO:0035865	cellular response to potassium ion	biological process	IEP[19342457]	2
GO:0016125	sterol metabolic process	biological process	TAS	2
GO:0020037	heme binding	molecular function	IBA; IC[2256920]	3
GO:0005506	iron ion binding	molecular function	IEA	5
GO:0047783	corticosterone 18-monooxygenase activity	molecular function	IBA	1
GO:0005739	mitochondrion	cellular component	IDA[2256920]	29
GO:0032342	aldosterone biosynthetic process	biological process	IDA[2256920]; IMP[19342457]	1
GO:0005743	mitochondrial inner membrane	cellular component	IC[8506298]; TAS[15026188]	3
GO:0006805	xenobiotic metabolic process	biological process	TAS	9
GO:0071375	cellular response to peptide hormone stimulus	biological process	IBA	1
GO:0032870	cellular response to hormone stimulus	biological process	IEP[19342457]	2
GO:0008217	regulation of blood pressure	biological process	IMP[2022736]	5
GO:0006704	glucocorticoid biosynthetic process	biological process	TAS	1
GO:0008203	cholesterol metabolic process	biological process	IBA	7
GO:0004507	steroid 11-beta-monooxygenase activity	molecular function	IDA[2256920\|8506298]; IMP[2022736]	1
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0042593	glucose homeostasis	biological process	TAS[16114325]	7
GO:0034651	cortisol biosynthetic process	biological process	IDA[8506298]; IMP[2022736\|19342457]	1
GO:0006955	immune response	biological process	TAS[12452430]	6
GO:0044550	secondary metabolite biosynthetic process	biological process	IBA	1
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	molecular function	IBA	1
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0006700	C21-steroid hormone biosynthetic process	biological process	IDA[2256920]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in PTSDgene
hsa00140	C21-Steroid hormone metabolism	1
hsa00150	Androgen and estrogen metabolism	2

Gene related interactors from protein-protein interactions data in PINA v2 (count: 1)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CYP11B1	CYP11B2	No	--	--	10411633