PTSDgene database

SNP Report

Basic Info
Name rs4511180 dbSNP Ensembl
Location 1:202180311 - 202180311(+)
Variant Seq G
Ancestral Allele G
Ref Seq A
Minor Allele Frequence 0.292931
Annotation non_coding_transcript_exon_variant; intron_variant; non_coding_transcript_variant
Variant Effect non_coding_transcript_exon_variant(ENST00000482597); intron_variant(ENST00000490225); non_coding_transcript_variant(ENST00000490225, ENST00000482597)
SIFT Annotation deleterious_-_low_confidence; tolerated_-_low_confidence; deleterious; tolerated
SIFT Variant Effect deleterious_-_low_confidence(ENST00000435759, ENST00000309017, ENST00000480836, ENST00000486116, ENST00000496197); tolerated_-_low_confidence(ENST00000467283); deleterious(ENST00000462815, ENST00000629151); tolerated(ENST00000495688, ENST00000477554, ENST00000367279, ENST00000492451, ENST00000464870)
PolyPhen Annotation benign; possibly_damaging
PolyPhen Variant Effect benign(ENST00000495688, ENST00000467283, ENST00000309017, ENST00000477554, ENST00000486116, ENST00000367279, ENST00000492451, ENST00000464870); possibly_damaging(ENST00000462815, ENST00000435759, ENST00000480836, ENST00000496197, ENST00000629151)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Weak transcription;Enhancers
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD In subjects of African: P-value=7.7E-07. In subjects of African: P-value=7.7E-07. It met the threshold for suggestive evidence of association ...... It met the threshold for suggestive evidence of association (P-value<5E-06). More... Trend
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Nievergelt, C. M.,2015 PTSD Childhood trauma Gene and childhood trauma interaction: P-value<0.05 in any s...... Gene and childhood trauma interaction: P-value<0.05 in any subjects. More... It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
PTPRVP protein tyrosine phosphatase, receptor type V, pseudogene 1q32.1 1(0/0/1)

SNPs in LD with rs4511180 (count: 12)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 1)

LD-proxies (count: 11)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx