Study Report
Study Information
Basic Info
| Reference |
Koenen, K. C.,2009 PMID: 19228812
|
| Citation |
Koenen, K. C., et al. (2009). "Modification of the association between serotonin transporter genotype and risk of posttraumatic stress disorder in adults by county-level social environment." Am J Epidemiol 169(6): 704-711. |
| Phenotype |
Current diagnosis of PTSD |
| Trauma |
2004 Florida hurricane |
| Study Design |
Case-control |
| Study Type |
Candidate gene association study, Gene-environment interaction study |
| Sample Size |
590 participants |
| SNP/Marker Size |
1 Variant |
| Predominant Ethnicity |
Caucasian |
| Population |
531 White, 56 other (Included African-American, Hispanic, and Asian) |
| Gender |
63.6% females |
| Age |
22.7% < 60 years |
Detail Info
| Sample Diagnosis |
NWS PTSD module |
| Related Diagnostic Tools |
Current PTSD (past 6 months) was assessed using the National Women's Study PTSD module, a widely used measure in population-based epidemiologic research. Social support 6 months before the hurricanes was assessed with a modified 5-item version of the Medical Outcomes Study module. |
| Sample Status |
Data for this study were collected in a random digit dialing study of residents of 33 Florida counties in 2004, when Florida was hit by hurricanes Jeanne, Ivan, Frances, and Charley in rapid succession. We used the Waksberg random digit dialing method to select households with telephones to be screened for potential participation. |
| Controls Exposed |
Yes |
| Replication Size |
None |
| Result Summary |
There was a significant interaction between 5-HTTLPR genotype and both crime rate (odds ratio=2.68, 95% confidence interval=1.09, 6.57) and unemployment rate (odds ratio=3.67, 95% confidence interval=1.42, 9.50) in logistic regression models predicting PTSD risk, after adjustment for individual-level determinants of PTSD. Stratified analyses indicated that the 's' allele of the 5-HTTLPR polymorphism was associated with decreased risk of PTSD in low-risk environments (low crime/unemployment rates) but increased risk of PTSD in high-risk environments. These results suggest that social environment modifies the effect of 5-HTTLPR genotype on PTSD risk. |
| Potential Biomarker |
None |
Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
| Marker |
Phenotype |
Related Gene |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
Current diagnosis of PTSD |
SLC6A4 |
In every model, P>0.05. |
There was no significant main effect for 5-HTTLPR genotype.
There was no significant main effect for 5-HTTLPR genotype.
|
Non-significant |
Gene * Environment result reported by this study (count: 2)
| Marker |
Phenotype |
Related Gene |
Environment |
Statistical Values |
Author Comments |
Marker's Category |
|
5-HTTLPR
|
Current Diagnosis of PTSD |
SLC6A4 |
Unemployment rate |
Multivariable logistic regression models for unemployment rate and PTSD: in the interaction model, 5-HTTLPR genotype x unemployment rate: P-value=0.007. Stratified analyses: s' allele of 5-HTTLPR living in low-unemployment counties:OR=0.35, 95%CI=0.14-0.87; in high-unemployment counties: OR=1.46, 95%CI=0.82-2.61. |
Multivariable logistic regression models for unemployment ra......
Multivariable logistic regression models for unemployment rate and PTSD: in the interaction model, the interaction term for 5-HTTLPR genotype x unemployment rate was significant. Figure 2 presents the prevalence of PTSD for persons from counties with high unemployment versus those with low unemployment by 5-HTTLPR genotype. Stratified analyses showed that the s' allele of 5-HTTLPR predicted decreased risk of PTSD among persons living in low-unemployment counties but increased risk in high-unemployment counties. Note that because of the loss of power in stratified analyses, only the effect of 5-HTTLPR genotype in low-unemployment counties was statistically significant.
More...
|
Significant |
|
5-HTTLPR
|
Current Diagnosis of PTSD |
SLC6A4 |
Crime rate |
Multivariable logistic regression models for crime rate and PTSD: in the interaction model, 5-HTTLPR genotype x crime rate: P-value=0.03. Stratified analyses: s' allele of 5-HTTLPR living in low-crime counties), odds ratio (OR)=0.61, 95%CI=0.34, 1.10; in high-crime counties: OR=1.54, 95%CI=0.72, 3.30. |
Multivariable logistic regression models for crime rate and ......
Multivariable logistic regression models for crime rate and PTSD: In the interaction model, the interaction term for 5-HTTLPR genotype x crime rate was significant. Figure 1 presents the prevalence of PTSD for persons from high-crime-rate counties versus persons from low-crime-rate counties by 5-HTTLPR genotype. Stratified analyses showed that the s' allele of 5-HTTLPR predicted decreased risk of PTSD among persons living in low-crime counties but increased risk in high-crime counties.
More...
|
Significant |
