PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Wolf, E. J.,2013 PMID: 24123648
Citation	Wolf, E. J., et al. (2013). "Corticotropin releasing hormone receptor 2 (CRHR-2) gene is associated with decreased risk and severity of posttraumatic stress disorder in women." Depress Anxiety 30(12): 1161-1169.
Phenotype	PTSD diagnosis, Latent PTSD Severity
Trauma	Lifetime traumatic events
Study Design	Case-control
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	296 cases, 195 controls
SNP/Marker Size	31 SNPs
Predominant Ethnicity	Caucasian
Population	White non-Hispanic
Gender	Case: 217 males and 79 females, Control: 102 males and 93 females
Age	Overall: mean age= 51.95 years,SD= 11.06

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	Clinician Administered PTSD Scale (CAPS), Traumatic Life Events Questionnaire (TLEQ)
Sample Status	The current study was based on 491 of these individuals who reported lifetime exposure to a traumatic event and had valid lifetime PTSD interview data.
Controls Exposed	Yes
Replication Size	None
Result Summary	Ten SNPs showed nominally significant evidence of association with PTSD in the full sample and two SNPs (rs8192496 and rs2190242) were significant after permutation-based multiple testing correction (uncorrected P-value= .0004 and .0005, odds ratios= .60 and .58, respectively). Analyses stratified by sex revealed that the effect was specific to women, who comprised 35% of the sample (uncorrected P-value= 0.0003 and 0.0002, odds ratios= 0.41 and 0.35, respectively). Two additional SNPs (rs2267715 and rs2284218) also showed significant association with PTSD in women (both uncorrected P-value= 0.001, both odds ratios= 0.48). Results suggest that CRHR-2 variants may affect risk for PTSD in women by attenuating the stress response and reducing symptoms of the disorder. This was the first candidate gene study to evaluate the association between CRHR-2 and PTSD.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 14)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs2284216	PTSD diagnosis	CRHR2	OR=0.54, 95% CI: 0.34-0.85, P-value uncorrected=0.007, P-value corrected=0.11	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More...	Significant
rs8192496	Latent PTSD Severity	CRHR2	Structural equation modeling: unstandardized B= -1.78, P-value= 0.01. In women: unstandardized B= -2.86, P-value= 0.01. In men: unstandardized B=-0.86, P-value= 0.30	The SNP showed a significant association with PTSD severity,...... The SNP showed a significant association with PTSD severity, remained significant after correction for multiple testing. These associations to be significant in women but not men. More...	Significant
rs2284218	Latent PTSD Severity	CRHR2	Structural equation modeling: In women: unstandardized B= -2.89, P-value= 0.005. In men: unstandardized B= -0.95, P-value= 0.25	The SNP showed a significant association with PTSD severity ...... The SNP showed a significant association with PTSD severity only in women. More...	Significant
rs2267715	Latent PTSD Severity	CRHR2	Structural equation modeling: In women: unstandardized B= -3.07, P-value= 0.003. In men: unstandardized B= -0.78, P-value= 0.35	The SNP showed a significant association with PTSD severity ...... The SNP showed a significant association with PTSD severity only in women. More...	Significant
rs2267717	PTSD diagnosis	CRHR2	OR=0.64, 95% CI: 0.43-0.95, P-value uncorrected=0.03, P-value corrected=0.34	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More...	Significant
rs2190242	Latent PTSD Severity	CRHR2	Structural equation modeling: unstandardized B= -1.96, P-value= 0.01. In women: unstandardized B= -4.26, P-value= 0.001. In men: unstandardized B= -0.50, P-value= 0.57	The SNP showed a significant association with PTSD severity,...... The SNP showed a significant association with PTSD severity, remained significant after correction for multiple testing. These associations to be significant in women but not men. More...	Significant
rs2240404	PTSD diagnosis	CRHR2	OR=0.65, 95% CI: 0.44-0.95, P-value uncorrected=0.03, P-value corrected=0.33	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More...	Significant
rs2267715	PTSD diagnosis	CRHR2	OR=0.68, 95% CI: 0.52-0.89, P-value uncorrected=0.004, P-value corrected=0.07. In women: OR= 0.48, 95% CI: 0.30-0.74, P-value= 0.001, corrected P-value= .02. In men: OR= 0.87, 95% CI: 0.62-1.24, P-value= 0.44.	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. These associations to be significant in women but not men. More...	Significant
rs2190242	PTSD diagnosis	CRHR2	X²=12.06 OR=0.58, 95% CI: 0.42-0.79, P-value uncorrected=0.0005, P-value corrected=0.01. In women: OR= 0.35, 95% CI: 0.20-0.62, P-value= 0.0002, corrected P-value= .004; In men: OR= 0.75, 95% CI: 0.50-1.13, P-value=0.17.	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, the minor allele (C) of rs2190242 was associated with reduced risk for PTSD, remained significant after correction for multiple testing. These associations to be significant in women but not men. More...	Significant
rs3779250	PTSD diagnosis	CRHR2	OR=0.69, 95% CI: 0.52-0.90, P-value uncorrected=0.006, P-value corrected=0.10	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More...	Significant
rs973002	PTSD diagnosis	CRHR2	OR=0.65, 95% CI: 0.46-0.92, P-value uncorrected=0.01, P-value corrected=0.21	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More...	Significant
rs8192496	PTSD diagnosis	CRHR2	X²=12.55, OR=0.60, 95% CI: 0.45-0.80, P-value uncorrected=0.0004, P-value corrected=0.01. In women: OR = 0.41, 95% CI: 0.25-0.67, P-value= .0003, corrected P-value= .006; In men: OR= 0.78, 95% CI: 0.54-1.13, P-value=0.19.	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, the minor allele (G) of rs8192496 was associated with reduced risk for PTSD, remained significant after correction for multiple testing. These associations to be significant in women but not men. More...	Significant
rs2284218	PTSD diagnosis	CRHR2	OR=0.67, 95% CI: 0.52-0.88, P-value uncorrected=0.003, P-value corrected=0.05. In women: OR= 0.48, 95% CI: 0.31-0.75, P-value=0.001, corrected P-value= 0.02.	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. It showed a female-specific association with PTSD that withstood permutation testing. More...	Significant
rs2284220	PTSD diagnosis	CRHR2	OR=0.64, 95% CI: 0.44-0.93, P-value uncorrected=0.02, P-value corrected=0.24	It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More...	Significant

Gene * Environment result reported by this study (count: 2)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs8192496	Latent PTSD Severity	CRHR2	Lifetime trauma exposure	Structural equation modeling: unstandardized B= 0.22, P-value= 0.09.	Trauma exposure did not interact with the SNP to predict PTS...... Trauma exposure did not interact with the SNP to predict PTSD severity. More...	Non-significant
rs2190242	Latent PTSD Severity	CRHR2	Lifetime trauma exposure	Structural equation modeling: unstandardized B= 0.15, P-value= 0.31.	Trauma exposure did not interact with the SNP to predict PTS...... Trauma exposure did not interact with the SNP to predict PTSD severity. More...	Non-significant