PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Wolf, E. J., et al. (2013). "Corticotropin releasing hormone receptor 2 (CRHR-2) gene is associated with decreased risk and severity of posttraumatic stress disorder in women." Depress Anxiety 30(12): 1161-1169.
Phenotype PTSD diagnosis, Latent PTSD Severity
Trauma Lifetime traumatic events
Study Design Case-control
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 296 cases, 195 controls
SNP/Marker Size 31 SNPs
Predominant Ethnicity Caucasian
Population White non-Hispanic
Gender Case: 217 males and 79 females, Control: 102 males and 93 females
Age Overall: mean age= 51.95 years,SD= 11.06

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 14)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs2284216 PTSD diagnosis CRHR2 OR=0.54, 95% CI: 0.34-0.85, P-value uncorrected=0.007, P-value corrected=0.11 It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More... Significant
rs8192496 Latent PTSD Severity CRHR2 Structural equation modeling: unstandardized B= -1.78, P-value= 0.01. In women: unstandardized B= -2.86, P-value= 0.01. In men: unstandardized B=-0.86, P-value= 0.30 The SNP showed a significant association with PTSD severity,...... The SNP showed a significant association with PTSD severity, remained significant after correction for multiple testing. These associations to be significant in women but not men. More... Significant
rs2284218 Latent PTSD Severity CRHR2 Structural equation modeling: In women: unstandardized B= -2.89, P-value= 0.005. In men: unstandardized B= -0.95, P-value= 0.25 The SNP showed a significant association with PTSD severity ...... The SNP showed a significant association with PTSD severity only in women. More... Significant
rs2267715 Latent PTSD Severity CRHR2 Structural equation modeling: In women: unstandardized B= -3.07, P-value= 0.003. In men: unstandardized B= -0.78, P-value= 0.35 The SNP showed a significant association with PTSD severity ...... The SNP showed a significant association with PTSD severity only in women. More... Significant
rs2267717 PTSD diagnosis CRHR2 OR=0.64, 95% CI: 0.43-0.95, P-value uncorrected=0.03, P-value corrected=0.34 It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More... Significant
rs2190242 Latent PTSD Severity CRHR2 Structural equation modeling: unstandardized B= -1.96, P-value= 0.01. In women: unstandardized B= -4.26, P-value= 0.001. In men: unstandardized B= -0.50, P-value= 0.57 The SNP showed a significant association with PTSD severity,...... The SNP showed a significant association with PTSD severity, remained significant after correction for multiple testing. These associations to be significant in women but not men. More... Significant
rs2240404 PTSD diagnosis CRHR2 OR=0.65, 95% CI: 0.44-0.95, P-value uncorrected=0.03, P-value corrected=0.33 It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More... Significant
rs2267715 PTSD diagnosis CRHR2 OR=0.68, 95% CI: 0.52-0.89, P-value uncorrected=0.004, P-value corrected=0.07. In women: OR= 0.48, 95% CI: 0.30-0.74, P-value= 0.001, corrected P-value= .02. In men: OR= 0.87, 95% CI: 0.62-1.24, P-value= 0.44. It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. These associations to be significant in women but not men. More... Significant
rs2190242 PTSD diagnosis CRHR2 X2=12.06 OR=0.58, 95% CI: 0.42-0.79, P-value uncorrected=0.0005, P-value corrected=0.01. In women: OR= 0.35, 95% CI: 0.20-0.62, P-value= 0.0002, corrected P-value= .004; In men: OR= 0.75, 95% CI: 0.50-1.13, P-value=0.17. It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, the minor allele (C) of rs2190242 was associated with reduced risk for PTSD, remained significant after correction for multiple testing. These associations to be significant in women but not men. More... Significant
rs3779250 PTSD diagnosis CRHR2 OR=0.69, 95% CI: 0.52-0.90, P-value uncorrected=0.006, P-value corrected=0.10 It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More... Significant
rs973002 PTSD diagnosis CRHR2 OR=0.65, 95% CI: 0.46-0.92, P-value uncorrected=0.01, P-value corrected=0.21 It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More... Significant
rs8192496 PTSD diagnosis CRHR2 X2=12.55, OR=0.60, 95% CI: 0.45-0.80, P-value uncorrected=0.0004, P-value corrected=0.01. In women: OR = 0.41, 95% CI: 0.25-0.67, P-value= .0003, corrected P-value= .006; In men: OR= 0.78, 95% CI: 0.54-1.13, P-value=0.19. It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, the minor allele (G) of rs8192496 was associated with reduced risk for PTSD, remained significant after correction for multiple testing. These associations to be significant in women but not men. More... Significant
rs2284218 PTSD diagnosis CRHR2 OR=0.67, 95% CI: 0.52-0.88, P-value uncorrected=0.003, P-value corrected=0.05. In women: OR= 0.48, 95% CI: 0.31-0.75, P-value=0.001, corrected P-value= 0.02. It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. It showed a female-specific association with PTSD that withstood permutation testing. More... Significant
rs2284220 PTSD diagnosis CRHR2 OR=0.64, 95% CI: 0.44-0.93, P-value uncorrected=0.02, P-value corrected=0.24 It showed nominally significant associations with lifetime P...... It showed nominally significant associations with lifetime PTSD diagnosis, but didn't pass the multiple testing. More... Significant

Gene * Environment result reported by this study (count: 2)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
rs8192496 Latent PTSD Severity CRHR2 Lifetime trauma exposure Structural equation modeling: unstandardized B= 0.22, P-value= 0.09. Trauma exposure did not interact with the SNP to predict PTS...... Trauma exposure did not interact with the SNP to predict PTSD severity. More... Non-significant
rs2190242 Latent PTSD Severity CRHR2 Lifetime trauma exposure Structural equation modeling: unstandardized B= 0.15, P-value= 0.31. Trauma exposure did not interact with the SNP to predict PTS...... Trauma exposure did not interact with the SNP to predict PTSD severity. More... Non-significant