Gene Report

Basic Info

Approved Symbol	STMN1
Previous Symbol	"LAP18\|C1orf215"
Symbol Alias	"SMN\|OP18\|PR22\|PP19\|PP17\|Lag\|FLJ32206"
Approved Name	stathmin 1
Previous Name	"chromosome 1 open reading frame 215\|stathmin 1/oncoprotein 18"
Name Alias	oncoprotein 18
Location	1p36.11
Position	chr1:25884181-25906991, -1
External Links	HGNC: 6510 Entrez Gene: 3925 Ensembl: ENSG00000117632 UCSC: uc010oev.2
No. of Association Results	6 (Positive: 1; Negative: 5; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 6)

Reference	Phenotype	Marker	Gene's Category
Cao, C.,2013	Anxious arousal symptoms	rs182455	Non-significant
Cao, C.,2013	Avoidance symptoms	rs182455	Non-significant
Cao, C.,2013	Dysphoric arousal symptoms	rs182455	Non-significant
Cao, C.,2013	Emotional numbing symptoms	rs182455	Non-significant
Nievergelt, C. M.,2015	PTSD	rs4659395	Non-significant
Cao, C.,2013	Reexperiencing symptoms	rs182455	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs4659395	Non-significant

Gene functional annotation

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0005515	protein binding	molecular function	IPI[25416956]	169
GO:0015631	tubulin binding	molecular function	IDA[10675326]	1
GO:0007420	brain development	biological process	IEA	4
GO:0051493	regulation of cytoskeleton organization	biological process	IBA	1
GO:0000281	mitotic cytokinesis	biological process	IMP[25122120]	2
GO:0007019	microtubule depolymerization	biological process	IDA[9880330]	2
GO:0004871	signal transducer activity	molecular function	TAS[2917975\|8003023]	5
GO:0007409	axonogenesis	biological process	IEA	6
GO:0043005	neuron projection	cellular component	IBA	17
GO:0005829	cytosol	cellular component	IEA	78
GO:0070062	extracellular exosome	cellular component	IDA[20458337]	58
GO:0009615	response to virus	biological process	IEP[16548883]	4
GO:0005622	intracellular	cellular component	IDA	15
GO:0016020	membrane	cellular component	IEA	42
GO:0051272	positive regulation of cellular component movement	biological process	IEA	1
GO:0005874	microtubule	cellular component	IEA	8
GO:0007165	signal transduction	biological process	NAS[8003023]	34
GO:0031175	neuron projection development	biological process	IBA	8
GO:0031115	negative regulation of microtubule polymerization	biological process	IEA	1
GO:0035556	intracellular signal transduction	biological process	TAS[2917975]	10
GO:0007052	mitotic spindle organization	biological process	IDA[9271428]	1
GO:0005737	cytoplasm	cellular component	IBA	109

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04010	MAPK signaling pathway	13

Gene related interactors from protein-protein interactions data in PINA v2 (count: 23)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
STMN1	TRPC5	No	--	--	12858178
STMN1	VCAM1	No	--	association	19738201 , 22623428 , 22623428
STMN1	UBQLN4	No	--	--	16713569 , 16713569 , 16713569 , 16713569 , 16713569
STMN1	CDK2	No	--	--	21319273
STMN1	PRKACA	No	--	--	8376365
STMN1	MAPK3	No	--	--	8376365
STMN1	STAT3	No	--	--	16401721
STMN1	HLA-B	No	--	--	17353931
STMN1	PAN2	No	--	--	23398456
STMN1	SEPT2	No	--	--	21900206 , 21900206 , 21900206
STMN1	S100A16	No	biochemical	colocalization	22939629
STMN1	VCP	No	--	--	23383273
STMN1	CDKN1B	No	--	--	15652749 , 15652749 , 15652749
STMN1	NADKD1	No	biochemical	colocalization	22939629
STMN1	NDUFV1	No	biochemical	colocalization	22939629
STMN1	PPARG	No	--	--	20195357
STMN1	GLP1R	No	--	--	23864651
STMN1	CSNK2A1	No	--	--	8376365
STMN1	VHL	No	--	--	17353931
STMN1	UHMK1	No	--	--	7724523
STMN1	STIP1	No	biochemical	colocalization	22939629
STMN1	PINX1	No	--	--	17353931
STMN1	HPDL	No	biochemical	colocalization	22939629