PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Uddin, M.,2013 PMID: 23280952
Citation	Uddin, M., et al. (2013). "Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment." Depress Anxiety 30(3): 251-258.
Phenotype	Past month PTSD, Past month PTS severity, Correlations between chlidhood maltreatment and past month PTS severity
Trauma	Not mentioned.
Study Design	Case-control
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	495 adult participants
SNP/Marker Size	1 SNP
Predominant Ethnicity	Black, Caucasian
Population	11.7% were white, 83.1% were African American, and 5.2% reported belonging to another race/ethnic group
Gender	All females
Age	18 years or older

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	PTSD diagnosis was assessed via telephone using a structured diagnostic interview validated against the Clinician-Administered PTSD Scale for DSM-IV (CAPS), Participants were initially asked to identify potentially traumatic events (PTEs) that they experienced in the past from a list of 19 events, PTS severity was assessed by summing participants' ratings of the 17 posttraumatic symptoms on a scale indicating the degree to which the respondent had been bothered by a particular symptom as a result of the worst trauma, ranging from 1 (not at all) to 5 (extremely), Depressive symptoms were evaluated with a structured interview based on a modified version of Patient Health Questionnaire (PHQ-9), CM questions were drawn from the Conflict Tactics Scale (CTS), the Childhood Trauma Scale (CTQ), and Wyatt's eight-item interview guide as implemented by the Nurse's Health Study II.
Sample Status	Samples for this study were drawn from the Detroit Neighborhood Health Study (DNHS). The DNHS is a population-representative cohort study of adult residents residing in Detroit and has been described.
Controls Exposed	Not mentioned.
Replication Size	None
Result Summary	RESULTS: No significant main effects were observed for ADCYAP1R1 genotype on either PTSD/PTS severity. In contrast, a significant ADCYAP1R1 x CM interaction was observed for both past month PTSD and PTS severity, with carriers of the "C" allele showing enhanced risk for these outcomes among women exposed to CM. No significant main or interaction effects were observed for past month depression/depression severity. CONCLUSIONS: Genetic variation at the ADCYAP1R1 locus interacts with CM to shape risk of later PTSD, but not depression, among women. The molecular mechanisms contributing to this interaction require further investigation.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 2)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs2267735	Past month PTS severity	ADCYAP1R1	Linear regression model: P-value=0.805.	There was no significant association between ADCYAP1R1 genot...... There was no significant association between ADCYAP1R1 genotype and past month PTS severity in the linear regression analyses. More...	Non-significant
rs2267735	Past month PTSD	ADCYAP1R1	Logistic regression analyses of the effect of ADCAYP1R1 genotype and CM on PTSD, controlling for age, race, and past month depression: ADCYAP1R1 genotype P-value=0.60.	There was no significant association between ADCYAP1R1 genot...... There was no significant association between ADCYAP1R1 genotype and past month PTSD in the logistic regression analyses. More...	Non-significant

Gene * Environment result reported by this study (count: 3)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs2267735	Correlations between chlidhood maltreatment and past month PTS severity	ADCYAP1R1	Childhood maltreatment (CM)	CC versus GG group: z-value=2.071, P-value< .05; CC versus CG group: z-value=2.868, P-value< .01.	Stratification by ADCYAP1R1 genotype showed that these corre...... Stratification by ADCYAP1R1 genotype showed that these correlations were significant only among genotypes containing the "C" allele. Moreover, correlation coefficients were significantly higher in the CC versus GG group and in the CC versus CG group. More...	Significant
rs2267735	Past month PTSD	ADCYAP1R1	Childhood maltreatment (CM)	Logistic regression analyses of the effect of ADCAYP1R1 genotype and CM on PTSD, controlling for age, race, and past month depression: results from interaction effect analyses P-value=0.029, permutation P-value=0.030.	Results from interaction effect analyses showed that partici...... Results from interaction effect analyses showed that participants with one versus no "C" alleles at the ADCAYP1R1 rs2267735 locus showed a 17% increased odds of past month PTSD for every one-unit increase in CM score in the logistic regression model. Analyses based on African-American participants only showed similar results. More...	Significant
rs2267735	Past month PTS severity	ADCYAP1R1	Childhood maltreatment (CM)	Linear regression model: P-value=0.037.	Results were similar when PTS severity used as outcomes with...... Results were similar when PTS severity used as outcomes with PTSD as outcomes. More...	Significant