Gene Report

Basic Info

Approved Symbol	TPH1
Previous Symbol	"TPRH\|TPH"
Approved Name	tryptophan hydroxylase 1
Previous Name	tryptophan hydroxylase (tryptophan 5-monooxygenase)
Name Alias	tryptophan 5-monooxygenase
Location	11p15.3-p14
Position	chr11:18017564-18042426, -1
External Links	HGNC: 12008 Entrez Gene: 7166 Ensembl: ENSG00000129167 UCSC: uc001mnp.2
No. of Association Results	5 (Positive: 1; Negative: 4; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 5)

Reference	Phenotype	Marker	Gene's Category
Nelson, E. C.,2014	PTSD	rs17794760	Non-significant
Nievergelt, C. M.,2015	PTSD	rs544437	Non-significant
Solovieff, N.,2014	PTSD diagnosis	rs11606304	Non-significant
Solovieff, N.,2014	PTSD severity	rs11606304	Non-significant
Goenjian, A. K.,2012	PTSD-RI (PTSD symptoms)	rs1799913 ; rs2108977	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs544437	Non-significant

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0016597	amino acid binding	molecular function	IEA	3
GO:0042427	serotonin biosynthetic process	biological process	IEA	2
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0005506	iron ion binding	molecular function	IEA	5
GO:0004510	tryptophan 5-monooxygenase activity	molecular function	IEA	2
GO:0060749	mammary gland alveolus development	biological process	IEA	1
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	11
GO:0009072	aromatic amino acid family metabolic process	biological process	IEA	2
GO:0030279	negative regulation of ossification	biological process	IEA	2
GO:0045600	positive regulation of fat cell differentiation	biological process	IEA	2
GO:0046849	bone remodeling	biological process	IEA	1
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0007623	circadian rhythm	biological process	IEA	5
GO:0035902	response to immobilization stress	biological process	IEA	3
GO:0005829	cytosol	cellular component	TAS	78
GO:0043005	neuron projection	cellular component	IEA	17
GO:0046219	indolalkylamine biosynthetic process	biological process	TAS	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa00380	Tryptophan metabolism	6

Gene related interactors from protein-protein interactions data in PINA v2 (count: 2)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
TPH1	YWHAH	No	--	--	7499362
TPH1	YWHAZ	No	--	--	8101440 , 8101440