PTSDgene database

SNP Report

Basic Info
Name rs450378 dbSNP Ensembl
Location 7:51941038 - 51941038(+)
Variant Seq T
Ancestral Allele C
Ref Seq C
Minor Allele Frequence 0.119209
Annotation downstream_gene_variant
SIFT Annotation deleterious_-_low_confidence; tolerated
SIFT Variant Effect deleterious_-_low_confidence(ENST00000395540); tolerated(ENST00000632460, ENST00000265136, ENST00000441453, ENST00000395542)
PolyPhen Annotation benign; possibly_damaging
PolyPhen Variant Effect benign(ENST00000441453); possibly_damaging(ENST00000632460, ENST00000395540, ENST00000265136, ENST00000395542)
rSNP? No Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Inactive region
No. of Marker's Association Results 2 (Positive: 0; Negative: 1; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 2)
Reference Phenotype Statistical Values Author Comments Marker's Category
Xie, P.,2013 Lifetime PTSD Whole Cohort of European Americans: in GWAS,P-value=1.19E-0...... Whole Cohort of European Americans: in GWAS,P-value=1.19E-06,in replication,P-value=0.25,in combined, P-value=2.03E-04;Trauma Exposed European Americans: in GWAS,P-value=4.89E-06,in replication,P-value=0.41,in combined, P-value=5.59E-04. More... No significant signals was observed about this SNP. Genome-w...... No significant signals was observed about this SNP. Genome-wide association study analyses restricted to trauma-exposed individuals yielded very similar results. More... Trend
Almli, L. M.,2014 PTSD symptoms (mPSS) Linear regression, main effect P-value=0.97 Linear regression, main effect P-value=0.97 They did not replicate as main effects in associations with ...... They did not replicate as main effects in associations with PTSD symptoms in this study. More... Non-significant
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Almli, L. M.,2014 PTSD symptoms (mPSS) Childhood trauma Linear regression, GxE P-value(standard regression model)=0....... Linear regression, GxE P-value(standard regression model)=0.008, GxE P-value(adjusted with robust standard errors with R package geepack)=0.02. More... We found a significant genotype and environment interaction ...... We found a significant genotype and environment interaction (G x E) with childhood trauma in our AA population. More... Significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
COBL cordon-bleu WH2 repeat protein 7p12.2-p12.1 2(1/1/0)

SNPs in LD with rs450378 (count: 39)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 39)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
LRRC37A4P No Adipose Subcutaneous cis GTEx