PTSDgene database

SNP Report

Basic Info
Name rs10762479 dbSNP Ensembl
Location 10:51897888 - 51897888(+)
Variant Seq G
Ancestral Allele G
Ref Seq A
Minor Allele Frequence 0.306909
Annotation intron_variant
Variant Effect intron_variant(ENST00000401604, ENST00000373980, ENST00000373985, ENST00000373976)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000373980, ENST00000401604, ENST00000373985, ENST00000373976)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000373980, ENST00000401604, ENST00000373985, ENST00000373976)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Enhancers;Weak transcription
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Ashley-Koch, A. E.,2015 Current PTSD In meta-analysis: main effect P-value=1.60E-05. In meta-analysis: main effect P-value=1.60E-05. This SNP was nominally significant with current PTSD after m...... This SNP was nominally significant with current PTSD after mete-analysis of NHB and NHW subset (P-value More... Trend
G*E study related association result (count: 2)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Ashley-Koch, A. E.,2015 Current PTSD Childhood trauma Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.037; in NHW subset: snp and child trauma interaction P-value=0.94. More... Among the NHB, we observed nominally significant interaction...... Among the NHB, we observed nominally significant interactions with childhood trauma for PRKG1. More... Non-significant
Ashley-Koch, A. E.,2015 Current PTSD NTE (number of traumatic events) Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.61; in NHW subset: snp and total trauma interaction P-value=0.29. More... We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More... Non-significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
PRKG1 protein kinase, cGMP-dependent, type I 10q11.2 1(0/0/1)

SNPs in LD with rs10762479 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx