PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Kohrt, B. A., et al. (2015). "Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia." Int Rev Psychiatry 27(3): 180-196.
Phenotype PTSD (Total PCL-C score)
Trauma South Asian, low-income population, which has a high burden of trauma exposure
Study Design Case-control
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 682 participants
SNP/Marker Size 4 SNPs
Predominant Ethnicity Mongloid
Population Brahman, Chhetri, Dalit/Nepali, Janajati
Gender 347 males, 335 females
Age Mean age=37 years, SD=13.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs9296158 PTSD (Total PCL-C score) FKBP5 Main effect for PTSD symptoms: P-value=0.875. Analysis in the Chhetri-only group: P-value=0.0431. There was no significant main effect for PTSD symptoms. Howe...... There was no significant main effect for PTSD symptoms. However, analysis in the Chhetri-only group showed a significant result. More... Significant

Gene * Environment result reported by this study (count: 1)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
rs9296158 PTSD (Total PCL-C score) FKBP5 Childhood maltreatment (CM) When controlling for ethnicity and other covariates, rs9296158 with child maltreatment interaction on PTSD: P-value=0.552. Analysis in the Chhetri-only group: P-value=0.117. When controlling for ethnicity and other covariates, rs92961...... When controlling for ethnicity and other covariates, rs9296158 also showed a significant interaction effect with child maltreatment on PTSD. Analysis in the Chhetri-only group showed similar results. More... Non-significant