SNP Report
Basic Info
| Name | rs74572794 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 8:42774242 - 42774242(+) | ||
| Variant Seq | A | ||
| Ancestral Allele | C | ||
| Ref Seq | C | ||
| Minor Allele Frequence | 0.0595048 | ||
| Annotation | intron_variant | ||
| Variant Effect | intron_variant(ENST00000533810) | ||
| SIFT Annotation | deleterious | ||
| SIFT Variant Effect | deleterious(ENST00000534622, ENST00000276410) | ||
| PolyPhen Annotation | probably_damaging | ||
| PolyPhen Variant Effect | probably_damaging(ENST00000534622, ENST00000276410) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription;Enhancers | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 1; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Kimbrel, N. A.,2015 | PTSD | In the NHW sample, main effect: P-value=0.1012. In the NHW sample, main effect: P-value=0.1012. | No main effect was statistically significant among NHW parti...... No main effect was statistically significant among NHW participants. More... | Non-significant |
G*E study related association result (count: 1)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Kimbrel, N. A.,2015 | PTSD | Smoking status | GxE interactions among NHW participants: P-value=0.0152. GxE interactions among NHW participants: P-value=0.0152. | Nominally significant associations (p<.05) were observed, bu...... Nominally significant associations (p<.05) were observed, but it didn't met multiple-testing threshold. More... | Significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CHRNA6 | cholinergic receptor, nicotinic alpha 6 | 8p22 | 1(0/1/0) |
SNPs in LD with rs74572794 (count: 0)
SNP related eQTL (count: 1)