Gene Report

Basic Info

Approved Symbol	WWC1
Symbol Alias	"KIBRA\|KIAA0869\|PPP1R168"
Approved Name	WW and C2 domain containing 1
Previous Name	WW, C2 and coiled-coil domain containing 1
Name Alias	protein phosphatase 1, regulatory subunit 168
Location	5q34
Position	chr5:168291651-168472303, 1
External Links	HGNC: 29435 Entrez Gene: 23286 Ensembl: ENSG00000113645 UCSC: uc011den.2
No. of Association Results	6 (Positive: 6; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 6)

Reference	Phenotype	Marker	Gene's Category
Wilker, S.,2013	Current PTSD	rs10038727 ; rs4576167	Significant
Sumner, J. A.,2014	Lifetime PTSD	rs10038727	Significant
Wilker, S.,2013	PDS hyperarousal score	rs10038727 ; rs4576167	Significant
Wilker, S.,2013	PDS intrusion score	rs10038727 ; rs4576167	Significant
Nievergelt, C. M.,2015	PTSD	rs17551315	Significant
Wilker, S.,2013	PTSD diagnosis	rs10038727 ; rs4576167	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Sumner, J. A.,2014	Lifetime PTSD	Lifetime traumatic load	rs10038727 ; rs17551315	Non-significant

Gene functional annotation

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0035329	hippo signaling	biological process	TAS	3
GO:0032947	protein complex scaffold	molecular function	IDA[24682284]	2
GO:0005515	protein binding	molecular function	IPI[16684779\|17994011\|18190796\|18596123]	169
GO:0030010	establishment of cell polarity	biological process	TAS[24682284]	1
GO:0043410	positive regulation of MAPK cascade	biological process	IDA[18190796]	3
GO:0030674	protein binding, bridging	molecular function	IEA	2
GO:0043234	protein complex	cellular component	IEA	10
GO:0035330	regulation of hippo signaling	biological process	IMP[20159598]	1
GO:0035331	negative regulation of hippo signaling	biological process	IDA[24682284]	1
GO:0019900	kinase binding	molecular function	IPI[24682284]	1
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[24682284]	16
GO:0032587	ruffle membrane	cellular component	IDA[18190796]	1
GO:0006351	transcription, DNA-templated	biological process	IEA	21
GO:0032386	regulation of intracellular transport	biological process	TAS[24682284]	1
GO:0005829	cytosol	cellular component	IDA[24682284]; TAS	78
GO:0003713	transcription coactivator activity	molecular function	IDA[16684779]	4
GO:0016477	cell migration	biological process	IDA[18596123]	6
GO:0046621	negative regulation of organ growth	biological process	IMP[24682284]	2
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[18596123]	14
GO:0005737	cytoplasm	cellular component	IDA[16684779\|18190796]	109
GO:0005634	nucleus	cellular component	IDA[16684779\|18190796]	81

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 7)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
WWC1	TNIK	No	--	--	17043677 , 17043677
WWC1	CDC5L	No	--	--	17043677
WWC1	DLC1	No	--	--	16684779 , 16684779
WWC1	LATS2	No	--	--	21233212 , 21233212
WWC1	FEZ1	No	--	--	16484223 , 16484223 , 16484223
WWC1	FEZ2	No	--	--	16484223
WWC1	EXOC1	No	--	--	19885391