Gene Report

Basic Info

Approved Symbol	HTR1A
Previous Symbol	"ADRB2RL1\|ADRBRL1"
Symbol Alias	5-HT1A
Approved Name	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Previous Name	5-hydroxytryptamine (serotonin) receptor 1A
Location	5q12.3
Position	chr5:63960356-63962507, -1
External Links	HGNC: 5286 Entrez Gene: 3350 Ensembl: ENSG00000178394 UCSC: uc011cqt.3
No. of Association Results	1 (Positive: 0; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Donaldson, Z. R.,2016	PTSD diagnosis	rs6295	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Donaldson, Z. R.,2016	PTSD diagnosis	Childhood trauma	rs6295	Non-significant

Gene functional annotation

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0042428	serotonin metabolic process	biological process	ISS	3
GO:0042053	regulation of dopamine metabolic process	biological process	ISS	3
GO:0042310	vasoconstriction	biological process	IEA	2
GO:0008284	positive regulation of cell proliferation	biological process	TAS[1330092]	14
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IMP[22957663]	14
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0014062	regulation of serotonin secretion	biological process	ISS	1
GO:0035640	exploration behavior	biological process	ISS	2
GO:0007210	serotonin receptor signaling pathway	biological process	ISS	2
GO:0008283	cell proliferation	biological process	IEA	9
GO:0005515	protein binding	molecular function	IPI[22035699]	169
GO:0050795	regulation of behavior	biological process	IEA	2
GO:0004993	G-protein coupled serotonin receptor activity	molecular function	IDA[8393041]; IMP[22957663]	2
GO:0001662	behavioral fear response	biological process	ISS	7
GO:0005887	integral component of plasma membrane	cellular component	IDA[22957663]	36
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	biological process	IDA[8393041]	1
GO:0046883	regulation of hormone secretion	biological process	IEA	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in PTSDgene
hsa04080	Neuroactive ligand-receptor interaction	22

Gene related interactors from protein-protein interactions data in PINA v2 (count: 8)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
HTR1A	HTR1D	No	--	--	11854302 , 11854302
HTR1A	RHOA	No	--	--	17142836
HTR1A	FGFR1	No	--	--	22553035 , 22553035 , 22553035 , 22553035 , 22553035 , 22035699 , 22035699 , 22035699 , 22035699 , 22035699 , 22035699
HTR1A	UBC	No	--	--	17203973
HTR1A	S1PR1	No	--	--	11854302 , 11854302 , 11854302
HTR1A	S1PR3	No	--	--	11854302 , 11854302
HTR1A	HTR1B	No	--	--	11854302
HTR1A	GPR26	No	--	--	11854302 , 11854302