PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Mercer, K. B., et al. (2012). "Acute and posttraumatic stress symptoms in a prospective gene x environment study of a university campus shooting." Arch Gen Psychiatry 69(1): 89-97.
Phenotype Postshooting PTSD symptoms score (delta DEQ >1 month), Hyperarousal (2-4 week delta DEQ), Reexperiencing (2-4 week delta DEQ), Avoidance (2-4 week delta DEQ)
Trauma Campus shooting
Study Design Longitudinal study
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 204 participants
SNP/Marker Size 3 Variants
Predominant Ethnicity Caucasian, Black
Population 77.5% white, 13.7% black or African American, other races accounted for 8.9%.
Gender all female
Age Mean age=20.1 years, SD=2.6.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 4)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
STin2 Postshooting PTSD symptoms score (delta DEQ >1 month) SLC6A4 In all races or white participants only, P-value>0.05. We did not observe main effects for STin2 alone on PTSD symp...... We did not observe main effects for STin2 alone on PTSD symptom score (2-4 week or >1 month delta DEQ). More... Non-significant
5-HTTLPR Postshooting PTSD symptoms score (delta DEQ >1 month) SLC6A4 In all races or white participants only, P-value>0.05. We did not observe main effects for 5-HTTLPR alone on PTSD s...... We did not observe main effects for 5-HTTLPR alone on PTSD symptom score (2-4 week or >1 month delta DEQ). More... Non-significant
rs25531 Postshooting PTSD symptoms score (delta DEQ >1 month) SLC6A4 In all races or white participants only, rs25531 genotype P-value>0.05. We did not observe main effects for rs25531 alone on PTSD sy...... We did not observe main effects for rs25531 alone on PTSD symptom score (>1 month delta DEQ). More... Non-significant
5-HTTLPR multimarker Postshooting PTSD symptoms score (delta DEQ >1 month) SLC6A4 In all races or white participants only, P-value>0.05. Non-significant Non-significant Non-significant

Gene * Environment result reported by this study (count: 7)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
5-HTTLPR multimarker Avoidance (2-4 week delta DEQ) SLC6A4 Shooting exposure White participants only:P-value=0.003. Avoidance symptoms were statistically significant. Avoidance symptoms were statistically significant. Significant
5-HTTLPR multimarker Hyperarousal (2-4 week delta DEQ) SLC6A4 Shooting exposure White participants only:P-value=0.03. Hyperarousal symptoms were statistically significant. Hyperarousal symptoms were statistically significant. Significant
5-HTTLPR multimarker Reexperiencing (2-4 week delta DEQ) SLC6A4 Shooting exposure White participants only:P-value=0.1. Reexperiencing symptoms were not significantly different. Reexperiencing symptoms were not significantly different. Non-significant
rs25531 Postshooting PTSD symptoms score (delta DEQ >1 month) SLC6A4 Shooting exposure White participants only: P-value>0.01. Not significant. Not significant. Non-significant
5-HTTLPR multimarker Postshooting PTSD symptoms score (delta DEQ >1 month) SLC6A4 Shooting exposure White participants only: P-value>0.01. Not significant. Not significant. Non-significant
5-HTTLPR Postshooting PTSD symptoms score (delta DEQ >1 month) SLC6A4 Shooting exposure White participants only: P-value>0.01. Not significant. Not significant. Non-significant
STin2 Postshooting PTSD symptoms score (delta DEQ >1 month) SLC6A4 Shooting exposure White participants only: P-value>0.01. Not significant. Not significant. Non-significant