Gene Report

Basic Info

Approved Symbol	CHRNA2
Approved Name	cholinergic receptor, nicotinic alpha 2
Previous Name	"cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)\|cholinergic receptor, nicotinic, alpha 2 (neuronal)"
Name Alias	acetylcholine receptor, nicotinic, alpha 2 (neuronal)
Location	8p21
Position	chr8:27459761-27479883, -1
External Links	HGNC: 1956 Entrez Gene: 1135 Ensembl: ENSG00000120903 UCSC: uc010lur.3
No. of Association Results	1 (Positive: 1; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Kimbrel, N. A.,2015	PTSD	rs10104133 ; rs2565067 ; rs60646603 ; rs73679204	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Kimbrel, N. A.,2015	PTSD	Smoking status	rs10104133 ; rs2565067 ; rs60646603 ; rs73679204	Significant

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0035094	response to nicotine	biological process	IBA	11
GO:0008144	drug binding	molecular function	IEA	13
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0015464	acetylcholine receptor activity	molecular function	IDA[8906617]	8
GO:0098655	cation transmembrane transport	biological process	IDA[8906617]; IEA	8
GO:0030054	cell junction	cellular component	IEA	24
GO:0051291	protein heterooligomerization	biological process	IEA	4
GO:0016021	integral component of membrane	cellular component	NAS[8906617]	56
GO:0007271	synaptic transmission, cholinergic	biological process	IBA	9
GO:0007165	signal transduction	biological process	IDA[8906617]	34
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0042166	acetylcholine binding	molecular function	IBA	8
GO:0005892	acetylcholine-gated channel complex	cellular component	IDA[8906617]	8
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0006811	ion transport	biological process	NAS[8906617]	10
GO:0099565	chemical synaptic transmission, postsynaptic	biological process	IDA[8906617]	7
GO:0004889	acetylcholine-activated cation-selective channel activity	molecular function	IDA[8906617]	8
GO:0007274	neuromuscular synaptic transmission	biological process	IBA	5

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 0)