PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Binder, E. B.,2008 PMID: 18349090
Citation	Binder, E. B., et al. (2008). "Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults." JAMA 299(11): 1291-1305.
Phenotype	PTSD Symptoms (PSS scores), PTSD Symptom Severity, Pearson correlation R value of CTQ Total Score and PSS Scores
Trauma	Various
Study Design	Cross-sectional study
Study Type	Candidate gene association study, Gene-environment interaction study
Sample Size	900 patients
SNP/Marker Size	11 SNPs
Predominant Ethnicity	Black(>95%)
Population	Black, White, Hispanic or Latino, Asian, Mixed and others (American Indian)
Gender	384 male and 516 female
Age	Mean age=40.8 years,SD=13.8.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	Modified PTSD Symptom Scale (PSS); The Clinician Administered PTSD Scale (CAPS); Beck Depression Inventory (BDI);The traumatic events inventory (TEI); The Childhood Trauma Questionnaire (CTQ); Dexamethasone Suppression Test(DST).
Sample Status	Screen interviews were completed approached while in the waiting rooms of primary care or obstetrical-gynecological clinics of Grady Memorial Hospital in Atlanta,Georgia, between 2005 and 2007. All patients were nonpsychiatric clinic.
Controls Exposed	NA
Replication Size	None
Result Summary	RESULTS: Level of child abuse and non-child abuse trauma each separately predicted level of adult PTSD symptomatology (mean [SD], PTSD Symptom Scale for no child abuse, 8.03 [10.48] vs > or =2 types of abuse, 20.93 [14.32]; and for no non-child abuse trauma, 3.58 [6.27] vs > or =4 types, 16.74 [12.90]; P-value < .001). Although FKBP5 SNPs did not directly predict PTSD symptom outcome or interact with level of non-child abuse trauma to predict PTSD symptom severity, 4 SNPs in the FKBP5 locus significantly interacted (rs9296158, rs3800373, rs1360780, and rs9470080; minimum P-value = .0004) with the severity of child abuse to predict level of adult PTSD symptoms after correcting for multiple testing. This gene x environment interaction remained significant when controlling for depression severity scores, age, sex, levels of non-child abuse trauma exposure, and genetic ancestry. This genetic interaction was also paralleled by FKBP5 genotype-dependent and PTSD-dependent effects on glucocorticoid receptor sensitivity, measured by the dexamethasone suppression test. CONCLUSIONS: Four SNPs of the FKBP5 gene interacted with severity of child abuse as a predictor of adult PTSD symptoms. There were no main effects of the SNPs on PTSD symptoms and no significant genetic interactions with level of non-child abuse trauma as predictor of adult PTSD symptoms, suggesting a potential gene-childhood environment interaction for adult PTSD.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 11)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs242924	PTSD symptom severity	CRHR1	No available detail information.	It showed a non-significant main effect on PTSD symptom seve...... It showed a non-significant main effect on PTSD symptom severity. More...	Non-significant
rs7209436	PTSD symptom severity	CRHR1	No available detail information.	It showed a non-significant main effect on PTSD symptom seve...... It showed a non-significant main effect on PTSD symptom severity. More...	Non-significant
rs1360780	PTSD Symptoms (PSS scores)	FKBP5	No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant
rs1334894	PTSD Symptoms (PSS scores)	FKBP5	No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant
rs737054	PTSD Symptoms (PSS scores)	FKBP5	No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant
rs9296158	PTSD Symptoms (PSS scores)	FKBP5	No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant
rs3800373	PTSD Symptoms (PSS scores)	FKBP5	No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant
rs4713916	PTSD Symptoms (PSS scores)	FKBP5	No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant
rs9470080	PTSD Symptoms (PSS scores)	FKBP5	No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant
rs992105	PTSD Symptoms (PSS scores)	FKBP5	No available detail information.	We found no significant main effect of FKBP5 genotypes on PS...... We found no significant main effect of FKBP5 genotypes on PSS total score. More...	Non-significant
rs110402	PTSD symptom severity	CRHR1	No available detail information.	It showed a non-significant main effect on PTSD symptom seve...... It showed a non-significant main effect on PTSD symptom severity. More...	Non-significant

Gene * Environment result reported by this study (count: 15)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs7209436	PTSD Symptom Severity	CRHR1	Child abuse	No available detail information.	It showed a non-significant interaction effect with child ab...... It showed a non-significant interaction effect with child abuse or non-child abuse trauma exposure on PTSD symptom severity. More...	Non-significant
rs242924	PTSD Symptom Severity	CRHR1	Child abuse	No available detail information.	It showed a non-significant interaction effect with child ab...... It showed a non-significant interaction effect with child abuse or non-child abuse trauma exposure on PTSD symptom severity. More...	Non-significant
rs110402	PTSD Symptom Severity	CRHR1	Child abuse	No available detail information.	It showed a non-significant interaction effect with child ab...... It showed a non-significant interaction effect with child abuse or non-child abuse trauma exposure on PTSD symptom severity. More...	Non-significant
rs1360780	PTSD Symptoms (PSS scores)	FKBP5	Child abuse	Interaction of it with child abuse level (to predict PTSD symptoms),an interaction P-value<.002 (after correcting for multiple tesing) . After adjusting for variables (controlling for BDI score as a continuous measure of depression symptoms or the 4-level non-child abuse trauma variable in addtion to age and sex) , the interaction P-value=0.07.	We identified the SNP that showed significant interactions w...... We identified the SNP that showed significant interactions with child abuse afterc orrecting for multiple testing. More...	Significant
rs9296158	PTSD Symptoms (PSS scores)	FKBP5	Child abuse	Interaction of it with child abuse level (to predict PTSD symptoms),an interaction P-value<.0004 (after correcting for multiple tesing).	We identified it as the the most significant SNP in the inte...... We identified it as the the most significant SNP in the interaction of KFBP5 polymorphisms with child abuse to predict PTSD symptoms. After adjusting for variables (controlling for BDI score as a continuous measure of depression symptoms or the 4-level non-child abuse trauma variable in addtion to age and sex) , the interaction terms of child abuse and rs9296158 remained significant. More...	Significant
rs9470080	PTSD Symptoms (PSS scores)	FKBP5	Child abuse	Interaction of it with child abuse level (to predict PTSD symptoms),an interaction P-value<.002 (after correcting for multiple tesing). After adjusting for variables (controlling for BDI score as a continuous measure of depression symptoms or the 4-level non-child abuse trauma variable in addtion to age and sex) , the interaction P-value=0.06.	We identified the SNP that showed significant interactions w...... We identified the SNP that showed significant interactions with child abuse afterc orrecting for multiple testing. More...	Significant
rs9470080	Pearson correlation R value of CTQ Total Score and PSS Scores	FKBP5	Child abuse	CC vs TT group: Z values for difference of correlation coefficient=1.9;CT vs CC group: Z values for difference of correlation coefficient=1.20;TT vs CT group: Z values for difference of correlation coefficient=1.03.	They observed non-significantly higher correlations of CTQ t...... They observed non-significantly higher correlations of CTQ total score and PSS score between some genotype group of this SNP. More...	Non-significant
rs3800373	PTSD Symptoms (PSS scores)	FKBP5	Child abuse	Interaction of it with child abuse level (to predict PTSD symptoms),an interaction P-value<.002 (after correcting for multiple tesing) .	We identified the SNP that showed significant interactions w...... We identified the SNP that showed significant interactions with child abuse afterc orrecting for multiple testing. After adjusting for variables (controlling for BDI score as a continuous measure of depression symptoms or the 4-level non-child abuse trauma variable in addtion to age and sex) , the interaction terms of child abuse and rs3800373 remained significant. More...	Significant
rs9296158	Pearson correlation R value of CTQ Total Score and PSS Scores	FKBP5	Child abuse	AA vs AG group: Z values for difference of correlation coefficient=1.17;AG vs GG group: Z values for difference of correlation coefficient=2.35, P-value<0.05;AA vs GG group: Z values for difference of correlation coefficient=3.00, P-value<0.01	They observed significantly higher correlations of CTQ total...... They observed significantly higher correlations of CTQ total score and PSS score between some genotype group of this SNP. More...	Significant
rs4713916	PTSD Symptoms (PSS scores)	FKBP5	Child abuse	No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant
rs3800373	Pearson correlation R value of CTQ Total Score and PSS Scores	FKBP5	Child abuse	AA vs CC group: Z values for difference of correlation coefficient=2.59, P-value<0.01;AC vs AA group: Z values for difference of correlation coefficient=2.30, P-value<0.05;CC vs AC group: Z values for difference of correlation coefficient=0.83.	They observed significantly higher correlations of CTQ total...... They observed significantly higher correlations of CTQ total score and PSS score between some genotype group of this SNP. More...	Significant
rs1334894	PTSD Symptoms (PSS scores)	FKBP5	Child abuse	No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant
rs737054	PTSD Symptoms (PSS scores)	FKBP5	Child abuse	No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant
rs1360780	Pearson correlation R value of CTQ Total Score and PSS Scores	FKBP5	Child abuse	CC vs TT group: Z values for difference of correlation coefficient=2.46, P-value<0.05;CT vs CC group: Z values for difference of correlation coefficient=2.33, P-value<0.05;TT vs CT group: Z values for difference of correlation coefficient=0.74.	They observed significantly higher correlations of CTQ total...... They observed significantly higher correlations of CTQ total score and PSS score between some genotype group of this SNP. More...	Significant
rs992105	PTSD Symptoms (PSS scores)	FKBP5	Child abuse	No available detail information.	No significant signals was observed about this SNP's interac...... No significant signals was observed about this SNP's interaction of FKBP5 with child abuse to predict PTSD symptoms. More...	Non-significant