Gene Report

Basic Info

Approved Symbol	LHX2
Symbol Alias	"LH-2\|hLhx2"
Approved Name	LIM homeobox 2
Location	9q33.3
Position	chr9:124001670-124033301, 1
External Links	HGNC: 6594 Entrez Gene: 9355 Ensembl: ENSG00000106689 UCSC: uc004boe.1
No. of Association Results	1 (Positive: 0; Negative: 0; trend: 1)
Annotation Type	Literature-origin, Mapped by Literature SNP

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	rs4838092	Trend

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs4838092	Non-significant

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0001942	hair follicle development	biological process	IEA	1
GO:2000678	negative regulation of transcription regulatory region DNA binding	biological process	IEA	1
GO:0009953	dorsal/ventral pattern formation	biological process	IEA	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA	25
GO:0045893	positive regulation of transcription, DNA-templated	biological process	ISS	11
GO:0006351	transcription, DNA-templated	biological process	IEA	21
GO:0021978	telencephalon regionalization	biological process	IEA	1
GO:0021772	olfactory bulb development	biological process	IEA	1
GO:0008270	zinc ion binding	molecular function	IEA	26
GO:0060041	retina development in camera-type eye	biological process	IEA	6
GO:0048675	axon extension	biological process	IEA	3
GO:0007498	mesoderm development	biological process	IEA	1
GO:0021987	cerebral cortex development	biological process	IEA	5
GO:0043565	sequence-specific DNA binding	molecular function	IEA	5
GO:0007411	axon guidance	biological process	IEA	16
GO:0005634	nucleus	cellular component	IEA	81
GO:0001076	transcription factor activity, RNA polymerase II transcription factor binding	molecular function	IEA	1
GO:0003682	chromatin binding	molecular function	IEA	6
GO:0045199	maintenance of epithelial cell apical/basal polarity	biological process	IEA	2
GO:0001843	neural tube closure	biological process	IEA	3

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 3)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
LHX2	RLIM	No	--	--	10431247
LHX2	CITED2	No	--	--	10593900 , 10593900 , 10593900 , 10593900
LHX2	LDB1	No	--	--	20211142