PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Cao, C., et al. (2017). "Support for the association between RORA gene polymorphisms and the DSM-5 posttraumatic stress disorder symptoms in male earthquake survivors in China." Asian J Psychiatr 25: 138-141.
Phenotype PTSD symptoms, Intrusion symptoms, Avoidance symptoms, Negative affect symptoms, Anhedonia symptoms, Externalizing behaviors symptoms, Dsyphoric arousal symptoms, Anxious arousal symptoms
Trauma 2008 Wenchuan earthquake
Study Design Cross-sectional study
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 1140 samples
SNP/Marker Size 1 SNP
Predominant Ethnicity Mongloid
Population Chinese
Gender 363 males, 777 females
Age Mean age=48.1 years,SD=10.0.

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 1)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs8042149 PTSD symptom severity RORA Females: B=-0.047, t=-0.709, P-value=0.479, Males: B=-0.047, t=-0.709, P-value=0.479. Main effect of this SNP was not associated with PTSD severit...... Main effect of this SNP was not associated with PTSD severity. More... Non-significant

Gene * Environment result reported by this study (count: 8)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
rs8042149 PTSD symptom severity RORA Earthquake exposure Females: B=0.058, t=0.818, P-value=0.414, Males: B=0.283, t=2.329, P-value=0.020. The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was associated with total PTSD symptoms in males. More... Significant
rs8042149 Intrusion symptom RORA Earthquake exposure Females: B=0.114, t=1.591, P-value=0.112, Males: B=0.191, t=1.562, P-value=0.119. The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was not significant. More... Non-significant
rs8042149 Avoidance symptom RORA Earthquake exposure Females: B=0.028, t=0.378, P-value=0.705, Males: B=0.173, t=1.402, P-value=0.162. The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was not significant. More... Non-significant
rs8042149 Negative affect symptom RORA Earthquake exposure Females: B=0.019, t=0.261, P-value=0.794, Males: B=0.293, t=2.371, P-value=0.018. The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was associated with severity of the negative affect symptoms in males. More... Significant
rs8042149 Anhedonia symptom RORA Earthquake exposure Females: B=0.043, t=0.588, P-value=0.557, Males: B=0.262, t=2.132, P-value=0.034. The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was associated with anhedonia symptoms in males. More... Significant
rs8042149 Externalizing behaviors symptom RORA Earthquake exposure Females: B=0.046, t=0.612, P-value=0.540, Males: B=0.224, t=1.805, P-value=0.072. The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was not significant. More... Non-significant
rs8042149 Anxious arousal symptom RORA Earthquake exposure Females: B=0.053, t=0.710, P-value=0.478, Males: B=0.186, t=1.502, P-value=0.134. The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was not significant. More... Non-significant
rs8042149 Dysphoria arousal symptom RORA Earthquake exposure Females: B=-0.049, t=-0.658, P-value=0.511, Males: B=0.325, t=2.642, P-value=0.009. The interaction of rs8042149 genotype x trauma exposure was ...... The interaction of rs8042149 genotype x trauma exposure was associated with dysphoric arousal symptoms in males. More... Significant