SNP Report
Basic Info
| Name | rs1006737 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 12:2236129 - 2236129(+) | ||
| Variant Seq | A | ||
| Ancestral Allele | G | ||
| Ref Seq | G | ||
| Minor Allele Frequence | 0.301518 | ||
| Annotation | intron_variant | ||
| Variant Effect | intron_variant(ENST00000399617, LRG_334t4, ENST00000399606, ENST00000399597, ENST00000327702, LRG_334t3, ENST00000402845, ENST00000399637, ENST00000399603, ENST00000399649, ENST00000344100, ENST00000335762, ENST00000399638, ENST00000347598, ENST00000399641, ENST00000399621, ENST00000480911, LRG_334t1, ENST00000399629, ENST00000399634, ENST00000399644, LRG_334t2, ENST00000406454, ENST00000399595, ENST00000399655, ENST00000399601, ENST00000399591) | ||
| SIFT Annotation | deleterious; tolerated | ||
| SIFT Variant Effect | deleterious(ENST00000399641, ENST00000344100, ENST00000399603, ENST00000399644, ENST00000399655, ENST00000399621, ENST00000399595, ENST00000402845, ENST00000399649, ENST00000399638, ENST00000399591, ENST00000399634, LRG_334t3, ENST00000399629, LRG_334t2, ENST00000399637, ENST00000335762, ENST00000347598, ENST00000399606, ENST00000399617, ENST00000399597, LRG_334t4, LRG_334t1, ENST00000327702, ENST00000406454, ENST00000399601); tolerated(ENST00000480911) | ||
| PolyPhen Annotation | benign; possibly_damaging; probably_damaging | ||
| PolyPhen Variant Effect | benign(ENST00000399641, ENST00000399603, ENST00000399595, ENST00000399649, ENST00000399591, ENST00000399629, ENST00000399617, ENST00000399597, LRG_334t4, ENST00000327702, ENST00000406454, ENST00000399601); possibly_damaging(ENST00000480911, ENST00000399644, ENST00000402845, ENST00000399638, LRG_334t3, LRG_334t2, ENST00000335762, ENST00000347598, ENST00000399606); probably_damaging(ENST00000344100, ENST00000399655, ENST00000399621, ENST00000399634, ENST00000399637, LRG_334t1) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Weak transcription;Enhancers | ||
| No. of Marker's Association Results | 2 (Positive: 0; Negative: 2; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | T4: joint test P-value> 0.05, variant P-value> 0.05. T4: joint test P-value> 0.05, variant P-value> 0.05. | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More... | Non-significant |
| Dunn, E. C.,2014 | Post-traumatic stress symptoms (PTS) | T4: joint test P-value> 0.05, variant P-value> 0.05. T4: joint test P-value> 0.05, variant P-value> 0.05. | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTS (P-values > 0.05). More... | Non-significant |
G*E study related association result (count: 2)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Dunn, E. C.,2014 | Post Traumatic Growth (PTG) | Hurricane exposure | T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. T4: joint test P-value> 0.05, GxE interaction P-value> 0.05. | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and PTG (P-values > 0.05). More... | Non-significant |
| Dunn, E. C.,2014 | Post-traumatic stress symptoms (PTS) | Hurricane exposure | Genetic variants and T3 or T4 PTS interaction: all P-values ...... Genetic variants and T3 or T4 PTS interaction: all P-values > 0.05. More... | We did not find any significant associations between the gen...... We did not find any significant associations between the genetic variants and T3 or T4 PTS (all P-values > 0.05). More... | Non-significant |
SNP related genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 12p13.3 | 2(0/2/0) |
SNPs in LD with rs1006737 (count: 4)
Literature-origin SNPs (count: 0)
LD-proxies (count: 4)
SNP related eQTL (count: 1)