PTSDgene database

SNP Report

Basic Info
Name rs2565067 dbSNP Ensembl
Location 8:27473602 - 27473602(+)
Variant Seq G
Ancestral Allele G
Ref Seq A
Minor Allele Frequence 0.199481
Annotation upstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
Variant Effect upstream_gene_variant(ENST00000522008); intron_variant(ENST00000520933, ENST00000520650, ENST00000524096, ENST00000521921, ENST00000240132, ENST00000407991, ENST00000518712, ENST00000520208, ENST00000523695); NMD_transcript_variant(ENST00000523695); non_coding_transcript_variant(ENST00000520650)
SIFT Annotation deleterious_-_low_confidence; tolerated_-_low_confidence; tolerated
SIFT Variant Effect deleterious_-_low_confidence(ENST00000523695, ENST00000521921, ENST00000524096); tolerated_-_low_confidence(ENST00000407991, ENST00000240132); tolerated(ENST00000518712)
PolyPhen Annotation benign
PolyPhen Variant Effect benign(ENST00000518712, ENST00000407991, ENST00000523695, ENST00000520208, ENST00000521921, ENST00000524096, ENST00000240132)
rSNP? Yes Link in rVarBase
Related Regulatory Elements Chromatin interactive region
Chromatin State Weak transcription
No. of Marker's Association Results 1 (Positive: 0; Negative: 1; Trend: 0)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Kimbrel, N. A.,2015 PTSD In the NHW sample, main effect: P-value=0.9635. In the NHW sample, main effect: P-value=0.9635. No main effect was statistically significant among NHW parti...... No main effect was statistically significant among NHW participants. More... Non-significant
G*E study related association result (count: 1)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Kimbrel, N. A.,2015 PTSD Smoking status GxE interactions among NHWB participants: P-value=0.007639. GxE interactions among NHWB participants: P-value=0.007639. Nominally significant associations (p<.05) were observed, bu...... Nominally significant associations (p<.05) were observed, but it didn't met multiple-testing threshold. More... Significant


SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Association Results (Positive/Negative/Trend)
CHRNA2 cholinergic receptor, nicotinic alpha 2 8p21 1(1/0/0)

SNPs in LD with rs2565067 (count: 0)

SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx