PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Variant Report

Basic Info

Name	APOE_euro4
Type	Point mutation
Related Gene	APOE
No. of Association Result	2 (Positive: 1; Negative: 1; Trend: 0)

Variant related studies

Normal genetic study related association result (count: 2)

Reference	Phenotype	Statistical Values	Author Comments	Marker's Category
Lyons, M. J.,2013	PTSD diagnosis	Secondary analyses, N=170, main effect for APOE genotype, B=...... Secondary analyses, N=170, main effect for APOE genotype, B=1.1265, P-value=0.58 (signif from GEE). More...	The main effect for apoE genotype was not significant in pre...... The main effect for apoE genotype was not significant in predicting the diagnosis of PTSD. More...	Non-significant
Lyons, M. J.,2013	PTSD symptomatology	Primary anlalyses, linear model, N=172, main effects for APO...... Primary anlalyses, linear model, N=172, main effects for APOE genotype: B=-1.766, P-value=0.02. More...	The main effect for apoE genotype was significant in primary...... The main effect for apoE genotype was significant in primary analyses. More...	Significant

Gene*Environment study related association results (count: 4)

Reference	Phenotype	Environment	Statistical Values	Author Comments	Marker's Category
Lyons, M. J.,2013	Diagnosis of PTSD	Combat exposure	Secondary anlalyses, N=170, interaction between combat expos...... Secondary anlalyses, N=170, interaction between combat exposure and APOE genotype: B=1.534, P-value=0.009 (signif from GEE). Using only White, non-Hispanic participants: P-value=0.001 More...	The interaction of combat exposure and apoE genotype was sig...... The interaction of combat exposure and apoE genotype was significant in secondary anlalyses for dianosis of PTSD. The interaction between combat exposure and apoE genotype remained a significant predictor of the diagnosis of PTSD using only White, non-Hispanic participants. More...	Significant
Kimbrel, N. A.,2015	Lifetime PTSD	Combat exposure (The Combat Exposure Scale, CES)	Interaction between APOE and combat exposure for lifetime PT...... Interaction between APOE and combat exposure for lifetime PTSD diagnosis: P-value= .0029, with high combat exposure: P-value=.0077. More...	No significant G x E effects were observed within the NHW sa...... No significant G x E effects were observed within the NHW sample. In contrast, significant G x E effects were observed for all three of the main outcomes examined in the NHB sample (all P's < .0083). A significant interaction between APOE and combat exposure was observed for lifetime PTSD diagnosis. For each additional euro4 allele, the odds of having a lifetime PTSD diagnosis increased by 1.61, but only among those with high combat exposure. The rates of lifetime PTSD among the high combat exposure group were 49.3% for participants with no euro4 alleles, 56.4% for those with one euro4 allele, and 92.3% for those with two euro4 alleles (Fig. 1). More...	Significant
Kimbrel, N. A.,2015	PTSD symptom severity	Combat exposure (The Combat Exposure Scale, CES)	APOE and combat exposure interaction to predict current PTSD...... APOE and combat exposure interaction to predict current PTSD symptom severity: P-value= .0009, with high combat exposure: P-value= .0011. More...	No significant G x E effects were observed within the NHW sa...... No significant G x E effects were observed within the NHW sample. APOE and combat exposure also interacted to predict current PTSD symptom severity. Again, as the number of euro4 alleles increased, the mean severity score on the DTS increased by 10.25 points, but only among those with high combat exposure. More...	Significant
Lyons, M. J.,2013	PTSD Symptomatology	Combat exposure	Primary anlalyses, N=172, interaction between combat exposur...... Primary anlalyses, N=172, interaction between combat exposure and APOE genotype: B=0.529, P-value=0.014 (signif from GEE). Using only White, non-Hispanic participants: P-value=0.008. More...	The interaction of combat exposure and apoE genotype was sig...... The interaction of combat exposure and apoE genotype was significant in primary anlalyses. The interaction between combat exposure and apoE genotype remained a significant predictor of the number of PTSD symptoms using only White, non-Hispanic participants. More...	Significant