SNP Report
Basic Info
| Name | rs12232346 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 15:34768262 - 34768262(+) | ||
| Variant Seq | C | ||
| Ancestral Allele | T | ||
| Ref Seq | T | ||
| Minor Allele Frequence | 0.182907 | ||
| Annotation | intron_variant; non_coding_transcript_variant | ||
| Variant Effect | intron_variant(ENST00000503496, ENST00000558707); non_coding_transcript_variant(ENST00000503496, ENST00000558707) | ||
| SIFT Annotation | tolerated | ||
| SIFT Variant Effect | tolerated(ENST00000290374) | ||
| PolyPhen Annotation | probably_damaging | ||
| PolyPhen Variant Effect | probably_damaging(ENST00000290374) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | n/a | ||
| Chromatin State | Bivalent Enhancer;Enhancers;Weak transcription | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 0; Trend: 1) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Ashley-Koch, A. E.,2015 | Current PTSD | In meta-analysis: main effect P-value=2.14E-06. In meta-analysis: main effect P-value=2.14E-06. |
This SNP was nominally significant with current PTSD after m......
This SNP was nominally significant with current PTSD after mete-analysis of NHB and NHW subset (P-value |
Trend |
G*E study related association result (count: 2)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Ashley-Koch, A. E.,2015 | Current PTSD | Childhood trauma | Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.94; in NHW subset: snp and child trauma interaction P-value=0.35. More... | We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More... | Non-significant |
| Ashley-Koch, A. E.,2015 | Current PTSD | NTE (number of traumatic events) | Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.62; in NHW subset: snp and total trauma interaction P-value=0.74. More... | We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More... | Non-significant |
SNP related genes (count: 0)
SNPs in LD with rs12232346 (count: 9)
Literature-origin SNPs (count: 0)
LD-proxies (count: 9)
SNP related eQTL (count: 1)