PTSDgene database

SNP Report

Basic Info
Name rs12232346 dbSNP Ensembl
Location 15:34768262 - 34768262(+)
Variant Seq C
Ancestral Allele T
Ref Seq T
Minor Allele Frequence 0.182907
Annotation intron_variant; non_coding_transcript_variant
Variant Effect intron_variant(ENST00000503496, ENST00000558707); non_coding_transcript_variant(ENST00000503496, ENST00000558707)
SIFT Annotation tolerated
SIFT Variant Effect tolerated(ENST00000290374)
PolyPhen Annotation probably_damaging
PolyPhen Variant Effect probably_damaging(ENST00000290374)
rSNP? Yes Link in rVarBase
Related Regulatory Elements n/a
Chromatin State Bivalent Enhancer;Enhancers;Weak transcription
No. of Marker's Association Results 1 (Positive: 0; Negative: 0; Trend: 1)
Source Literature

SNP related association results
Normal genetic study related association results (count: 1)
Reference Phenotype Statistical Values Author Comments Marker's Category
Ashley-Koch, A. E.,2015 Current PTSD In meta-analysis: main effect P-value=2.14E-06. In meta-analysis: main effect P-value=2.14E-06. This SNP was nominally significant with current PTSD after m...... This SNP was nominally significant with current PTSD after mete-analysis of NHB and NHW subset (P-value More... Trend
G*E study related association result (count: 2)
Reference Phenotype Environment Statistical Values Author Comments Marker's Category
Ashley-Koch, A. E.,2015 Current PTSD Childhood trauma Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and child trauma interaction P-value=0.94; in NHW subset: snp and child trauma interaction P-value=0.35. More... We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with childhood trauma. More... Non-significant
Ashley-Koch, A. E.,2015 Current PTSD NTE (number of traumatic events) Logistic regression (additive genetic model) in NHB subset: ...... Logistic regression (additive genetic model) in NHB subset: snp and total trauma interaction P-value=0.62; in NHW subset: snp and total trauma interaction P-value=0.74. More... We haven't observed significant evidence for gene*environmen...... We haven't observed significant evidence for gene*environment interactions of this snp with total trauma. More... Non-significant


SNP related genes (count: 0)

SNPs in LD with rs12232346 (count: 9)
The LD data used here is based on 1000 Genome Phase I. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 9)


SNP related eQTL (count: 1)
Gene Symbol Gene Existed in PTSDgene? Tissue Trans/Cis Source
RP11-259G18.3 No Adipose Subcutaneous cis GTEx