PTSDgene database

Pathway Enrichment Analysis Protein-Protein Interaction Analysis

Study Report

Study Information

Basic Info

Reference	Logue, M. W.,2013 PMID: 22869035
Citation	Logue, M. W., et al. (2013). "A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus." Mol Psychiatry 18(8): 937-942.
Phenotype	PTSD
Trauma	Combat (military veterans)
Study Design	Case-control
Study Type	Genome-wide association study, Gene-environment interaction study
Sample Size	295 cases and 196 controls
SNP/Marker Size	119,9491 SNPs(Detroit Neighborhood Health Study: 688,890)
Predominant Ethnicity	Caucasian, Black
Population	White non-Hispanic, African American
Gender	In discovery group and VA-African-Americans, not available. Detroit Neighborhood Health Study (N=521), 57% were female.
Age	Deatails are not available.

Detail Info

Sample Diagnosis	DSM-IV
Related Diagnostic Tools	The Clinician-Administered PTSD Scale (CAPS), Traumatic Life Events Questionnaire (TLEQ).
Sample Status	None
Controls Exposed	VA
Replication Size	Veteran cohort:43 cases and 41 controls;Detroit Neighborhood Health Study:100 cases and 421 controls
Result Summary	We describe the results of the first genome-wide association study of PTSD performed using trauma-exposed white non-Hispanic participants from a cohort of veterans and their intimate partners (295 cases and 196 controls). Several SNPs yielded evidence of association. One SNP (rs8042149), located in the retinoid-related orphan receptor alpha gene (RORA), reached genome-wide significance. Nominally significant associations were observed for other RORA SNPs in two African American replication samples-one from the veteran cohort (43 cases and 41 controls) and another independent cohort (100 cases and 421 controls). However, only the associated SNP from the veteran African American replication sample survived gene-level multiple testing correction. RORA has been implicated in prior GWAS studies of psychiatric disorders and is known to play an important role in neuroprotection and other behaviorally-relevant processes. This study represents an important step towards identifying the genetic underpinnings of PTSD.
Potential Biomarker	None

Genetic result reported by this study

Normal genetic result reported by this study (count: 14)

Marker	Phenotype	Related Gene	Statistical Values	Author Comments	Marker's Category
rs1021356	PTSD		In discovery group (allele): OR=1.9, P-value=4.9E-06.	It reached the suggestive level of significance in discovery...... It reached the suggestive level of significance in discovery group. More...	Trend
rs8024133	PTSD	RORA	In discovery group (allele): OR=1.9, P-value=8.8E-07.	It reached the suggestive level of significance in discovery...... It reached the suggestive level of significance in discovery group. More...	Trend
rs8041061	PTSD	RORA	In discovery group (allele): OR=2.0, P-value=1.6E-07.	It reached the suggestive level of significance in discovery...... It reached the suggestive level of significance in discovery group. More...	Trend
rs8042149	PTSD	RORA	In discovery group (allele): OR=2.1, P-value=2.5E-08. Bonferroni-corrected: P-value<4.16E-08. Logistic regression model that included NTE (number of traumatic events) and rs8042149: SNP's main effect, P-value=4.4E-08. In the VA-African-American sample: P-value=0.87.	It met genome-wide significance as well as Bonferroni-correc...... It met genome-wide significance as well as Bonferroni-corrected significance thresholds in discovery group. But it was not associated with PTSD in the VA-African-American sample. More...	Significant
rs893290	PTSD	RORA	In the African-Americans from the DNHS sample: OR=1.85, Nominal P-value=0.0052, Adjusted P-value=0.698.		Non-significant
rs12118091	PTSD		In discovery group (allele): OR=1.9, P-value=4.9E-06.	It reached the suggestive level of significance in discovery...... It reached the suggestive level of significance in discovery group. More...	Trend
rs4775301	PTSD	RORA	In discovery group (allele): OR=2.0, P-value=4.6E-07.	It reached the suggestive level of significance in discovery...... It reached the suggestive level of significance in discovery group. More...	Trend
rs72986828	PTSD	WDR5	In discovery group (allele): OR=3.5, P-value=5.6E-06.	It reached the suggestive level of significance in discovery...... It reached the suggestive level of significance in discovery group. More...	Trend
rs71355256	PTSD	C17orf97	In discovery group (allele): OR=3.7, P-value=4.3E-06.	It reached the suggestive level of significance in discovery...... It reached the suggestive level of significance in discovery group. More...	Trend
rs113508478	PTSD		In discovery group (allele): OR=1.9, P-value=7.4E-06.	It reached the suggestive level of significance in discovery...... It reached the suggestive level of significance in discovery group. More...	Trend
rs11071588	PTSD	RORA	In the VA-African-American sample: OR=3.81, Nominal P-value=6.77E-05, Adjusted P-value=0.018. In the Detroit sample: P-value=0.43.	It was found to be nominally significantly associated with P...... It was found to be nominally significantly associated with PTSD in the VA-African-American sample. It remained significant after multiple-testing correction. But it was not significatnt in the Detroit sample. More...	Trend
rs11071587	PTSD	RORA	In the VA-African-American sample: OR=4.03, Nominal P-value=0.00011, Adjusted P-value=0.029.	It was found to be nominally significantly associated with P...... It was found to be nominally significantly associated with PTSD in the VA-African-American sample. More...	Non-significant
rs11071561	PTSD	RORA	In discovery group (allele): OR=1.8, P-value=3.8-06.	It reached the suggestive level of significance in discovery...... It reached the suggestive level of significance in discovery group. More...	Trend
rs16942660	PTSD	RORA	In the African-Americans from the DNHS sample: OR=2.65, Nominal P-value=0.00090, Adjusted P-value=0.202.	In trauma-exposed African Americans from the DNHS, the most ...... In trauma-exposed African Americans from the DNHS, the most significant SNP associated with lifetime PTSD within RORA was rs16942660 633 kb from the peak SNP in African American's from the VA sample and 324 kb away from the peak SNP observed in the discovery sample of white non-Hispanic subjects. More...	Non-significant

Gene * Environment result reported by this study (count: 1)

Marker	Phenotype	Related Gene	Environment	Statistical Values	Author Comments	Marker's Category
rs8042149	PTSD	RORA	NTE (number of traumatic events)	Logistic regression model that included NTE (number of traumatic events) and rs8042149: SNP and NTE interaction, P-value=0.4576.	A further logistic model indicated that NTE and SNP interact...... A further logistic model indicated that NTE and SNP interaction was not significant More...	Non-significant