Gene Report

Basic Info

Approved Symbol	SLC6A3
Previous Symbol	DAT1
Symbol Alias	DAT
Approved Name	solute carrier family 6 (neurotransmitter transporter), member 3
Previous Name	"solute carrier family 6 (neurotransmitter transporter, dopamine), member 3\|dopamine transporter 1"
Name Alias	dopamine transporter
Location	5p15.3
Position	chr5:1392790-1445430, -1
External Links	HGNC: 11049 Entrez Gene: 6531 Ensembl: ENSG00000142319 UCSC: uc003jck.3
No. of Association Results	21 (Positive: 11; Negative: 10; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 21)

Reference	Phenotype	Marker	Gene's Category
Valente, N. L.,2011	PTSD	DAT_3'UTR_VNTR	Significant
Drury, S. S.,2009	PTSD category B symptom score	DAT_3'UTR_VNTR	Non-significant
Bailey, J. N.,2010	PTSD category B symptom score	DAT_3'UTR_VNTR	Non-significant
Drury, S. S.,2009	PTSD category C symptom score	DAT_3'UTR_VNTR	Non-significant
Bailey, J. N.,2010	PTSD category C symptom score	DAT_3'UTR_VNTR	Non-significant
Drury, S. S.,2009	PTSD category D symptom score	DAT_3'UTR_VNTR	Significant
Segman, R. H.,2002	PTSD diagnosis	DAT_3'UTR_VNTR	Significant
Drury, S. S.,2009	PTSD diagnosis	DAT_3'UTR_VNTR	Significant
Bailey, J. N.,2010	PTSD diagnosis	DAT_3'UTR_VNTR	Non-significant
Chang, S. C.,2012	PTSD diagnosis	DAT_3'UTR_VNTR	Significant
Drury, S. S.,2009	PTSD symptoms	DAT_3'UTR_VNTR	Significant
Bailey, J. N.,2010	PTSD symptoms	DAT_3'UTR_VNTR	Non-significant
Drury, S. S.,2013	PTSD category B symptom score	DAT_3'UTR_VNTR-rs27072, nine repeat-C	Non-significant
Drury, S. S.,2013	PTSD category C symptom score	DAT_3'UTR_VNTR-rs27072, nine repeat-C	Significant
Drury, S. S.,2013	PTSD category D symptom score	DAT_3'UTR_VNTR-rs27072, nine repeat-C	Significant
Drury, S. S.,2013	PTSD diagnosis	DAT_3'UTR_VNTR-rs27072, nine repeat-C	Significant
Drury, S. S.,2013	PTSD symptoms	DAT_3'UTR_VNTR-rs27072, nine repeat-C	Significant
Nievergelt, C. M.,2015	PTSD	rs144782362	Significant
Nelson, E. C.,2014	PTSD	rs6869645	Non-significant
Solovieff, N.,2014	PTSD diagnosis	rs11564751	Non-significant
Solovieff, N.,2014	PTSD severity	rs11564751	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Nievergelt, C. M.,2015	PTSD	Childhood trauma	rs144782362	Non-significant

Gene functional annotation

Gene related GO terms (count: 44)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0005329	dopamine transmembrane transporter activity	molecular function	IDA[15505207]	1
GO:0005102	receptor binding	molecular function	IEA	13
GO:0040018	positive regulation of multicellular organism growth	biological process	IEA	3
GO:0051721	protein phosphatase 2A binding	molecular function	IEA	3
GO:0005515	protein binding	molecular function	IPI[11343649\|12958153\|15505207\|17380124\|22163275]	169
GO:0042493	response to drug	biological process	IEA	25
GO:0005330	dopamine:sodium symporter activity	molecular function	IBA	2
GO:0010039	response to iron ion	biological process	IEA	2
GO:0046872	metal ion binding	molecular function	IEA	20
GO:0005886	plasma membrane	cellular component	IDA[11343649\|12958153]; TAS	99
GO:0016021	integral component of membrane	cellular component	TAS[8628395]	56
GO:0072488	ammonium transmembrane transport	biological process	IBA; IDA[15505207]; IEA	1
GO:0055085	transmembrane transport	biological process	TAS	14
GO:0021984	adenohypophysis development	biological process	IEA	2
GO:0051583	dopamine uptake involved in synaptic transmission	biological process	IBA	2
GO:0007595	lactation	biological process	IEA	3
GO:0009986	cell surface	cellular component	IDA[21399631]	21
GO:0098793	presynapse	cellular component	IBA	3
GO:0007568	aging	biological process	IEA	11
GO:0005887	integral component of plasma membrane	cellular component	IBA	36
GO:0045471	response to ethanol	biological process	IEA	18
GO:0035094	response to nicotine	biological process	IEA	11
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0032403	protein complex binding	molecular function	IEA	8
GO:0043025	neuronal cell body	cellular component	IDA[12958153]	18
GO:0002020	protease binding	molecular function	IEA	4
GO:0042420	dopamine catabolic process	biological process	IEA	5
GO:0030424	axon	cellular component	IDA[12958153]	16
GO:0051591	response to cAMP	biological process	IEA	2
GO:0035240	dopamine binding	molecular function	IEA	6
GO:0042220	response to cocaine	biological process	IEA	7
GO:0007608	sensory perception of smell	biological process	IEA	3
GO:0008504	monoamine transmembrane transporter activity	molecular function	IDA[16024787]	4
GO:0060134	prepulse inhibition	biological process	IEA	4
GO:0016600	flotillin complex	cellular component	IDA[21399631]	1
GO:0042416	dopamine biosynthetic process	biological process	IEA	2
GO:0015844	monoamine transport	biological process	IDA[16024787]	4
GO:0005737	cytoplasm	cellular component	TAS[10823899]	109
GO:0015872	dopamine transport	biological process	IDA[15505207]	2
GO:0042053	regulation of dopamine metabolic process	biological process	IEA	3
GO:0047485	protein N-terminus binding	molecular function	IEA	2
GO:0007626	locomotory behavior	biological process	IEA	9
GO:0008144	drug binding	molecular function	IEA	13
GO:0042136	neurotransmitter biosynthetic process	biological process	TAS	5

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 6)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
SLC6A3	EPN1	No	--	--	16885233
SLC6A3	TUBB1	No	--	--	16216085 , 16216085
SLC6A3	CAMK2A	No	--	--	22514303
SLC6A3	STX1A	No	--	--	15202772 , 18617632 , 18617632
SLC6A3	SNTA1	No	--	--	15123239
SLC6A3	PICK1	No	--	colocalization	11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649 , 11343649