Gene Report

Basic Info

Approved Symbol	CHRNA3
Approved Name	cholinergic receptor, nicotinic alpha 3
Previous Name	"cholinergic receptor, nicotinic, alpha polypeptide 3\|cholinergic receptor, nicotinic, alpha 3 (neuronal)"
Name Alias	acetylcholine receptor, nicotinic, alpha 3 (neuronal)
Location	15q24
Position	chr15:78593052-78621295, -1
External Links	HGNC: 1957 Entrez Gene: 1136 Ensembl: ENSG00000080644 UCSC: uc002bec.3
No. of Association Results	1 (Positive: 0; Negative: 1; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy, rSNP target

Gene related association results

Normal genetic study related association results (count: 1)

Reference	Phenotype	Marker	Gene's Category
Kimbrel, N. A.,2015	PTSD	rs62516743 ; rs75431302	Non-significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Kimbrel, N. A.,2015	PTSD	Smoking status	rs62516743 ; rs75431302	Significant

Gene functional annotation

Gene related GO terms (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0045211	postsynaptic membrane	cellular component	IEA	21
GO:0014056	regulation of acetylcholine secretion, neurotransmission	biological process	ISS	1
GO:0007626	locomotory behavior	biological process	ISS	9
GO:0051291	protein heterooligomerization	biological process	IEA	4
GO:0030425	dendrite	cellular component	ISS	19
GO:0007268	synaptic transmission	biological process	TAS	32
GO:0030054	cell junction	cellular component	IEA	24
GO:0015276	ligand-gated ion channel activity	molecular function	TAS[20438829]	4
GO:0048814	regulation of dendrite morphogenesis	biological process	ISS	3
GO:0004889	acetylcholine-activated cation-selective channel activity	molecular function	IDA[8906617]; TAS[20438829]	8
GO:0007271	synaptic transmission, cholinergic	biological process	IBA; ISS	9
GO:0014069	postsynaptic density	cellular component	ISS	11
GO:0042391	regulation of membrane potential	biological process	ISS	4
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	biological process	ISS	2
GO:0042166	acetylcholine binding	molecular function	IBA; IC[8906617]	8
GO:0042493	response to drug	biological process	IEA	25
GO:0007507	heart development	biological process	IEA	6
GO:0043025	neuronal cell body	cellular component	ISS	18
GO:0035095	behavioral response to nicotine	biological process	IMP[18227835]	4
GO:0007399	nervous system development	biological process	IMP[11450844]	7
GO:0060084	synaptic transmission involved in micturition	biological process	IMP[11450844]	2
GO:0006940	regulation of smooth muscle contraction	biological process	ISS	2
GO:0046982	protein heterodimerization activity	molecular function	IEA	10
GO:0008144	drug binding	molecular function	IEA	13
GO:0007165	signal transduction	biological process	IDA[8906617]	34
GO:0015464	acetylcholine receptor activity	molecular function	IDA[8906617]	8
GO:0016021	integral component of membrane	cellular component	NAS[8906617]	56
GO:0006811	ion transport	biological process	NAS[8906617]	10
GO:0010035	response to inorganic substance	biological process	IEA	1
GO:0060079	excitatory postsynaptic potential	biological process	ISS	5
GO:0098655	cation transmembrane transport	biological process	IDA[8906617]; IEA; TAS[20438829]	8
GO:0005886	plasma membrane	cellular component	TAS	99
GO:0005892	acetylcholine-gated channel complex	cellular component	IDA[8906617]	8
GO:0034220	ion transmembrane transport	biological process	TAS[20438829]	9

Gene related KEGG pathways (count: 0)

Gene related interactors from protein-protein interactions data in PINA v2 (count: 1)

Gene	Interactor	Interactor in PTSDgene?	Experiment Method	Interaction Type	PMID
CHRNA3	UBQLN1	No	--	--	16091357