PTSDgene database

Study Report

Study Information
Basic Info
Reference
Citation Humphreys, K. L., et al. (2014). "Race moderates the association of Catechol-O-methyltransferase genotype and posttraumatic stress disorder in preschool children." J Child Adolesc Psychopharmacol 24(8): 454-457.
Phenotype Total PTSD symptoms, PTSD diagnosis, PTSD category B symptom, PTSD category C symptom, PTSD category D symptom
Trauma Various
Study Design Case-control
Study Type Candidate gene association study, Gene-environment interaction study
Sample Size 171 children (152 African American and European American)
SNP/Marker Size 1 SNP
Predominant Ethnicity Caucasian, Black
Population Black, White, mixed, and other.
Gender met/met: 8 male and 4 female; val/met: 61 male and 37 female; val/val: 37 male and 24 female.
Age 3-6 years old

Detail Info

Genetic result reported by this study
Normal genetic result reported by this study (count: 3)
Marker Phenotype Related Gene Statistical Values Author Comments Marker's Category
rs4680 Total PTSD symptoms COMT In AA (n=104) group, COMT genotype, Wald X2=12.44, P-value=0.002. In EA (n=48) group, COMT genotye, Wald X2=10.99, P-value=0.004. Analyses within the AA group demonstrated that COMT genotype...... Analyses within the AA group demonstrated that COMT genotype was significantly associated with total PTSD symptoms. Individuals with met/met had significantly more PTSD symptoms than either other genotype (ps<0.014). Within the EA group, COMT genotype significantly predicted total PTSD symptoms. In this group, however, the val/val genotype group was associated with more PTSD symptoms, and significantly differed from both met groups (ps<0.013). More... Significant
rs4680 PTSD category D symptom COMT In AA (n=104) group, COMT genotype, Wald X2=7.84, P-value=0.02. In EA (n=48) group, COMT genotye, Wald X2=6.19, P-value=0.045. A significant effect was found for Criterion D symptoms in A...... A significant effect was found for Criterion D symptoms in AA group and EA group separately. More... Significant
rs4680 PTSD diagnosis COMT In African American, logistic regression, P-value=0.07; in European American, logistic regression, P-value=0.05. The logistic regression for COMT genotype by PTSD diagnosis ...... The logistic regression for COMT genotype by PTSD diagnosis did not terminate because of quasicomplete separation in the data (all AA children with met/met genotype met criteria for PTSD; no EA children with the met/met genotype met criteria for PTSD) (see Table 1). More... Non-significant

Gene * Environment result reported by this study (count: 4)
Marker Phenotype Related Gene Environment Statistical Values Author Comments Marker's Category
rs4680 PTSD category D symptom COMT Race Wald X2=10.47, P-value=0.005 A significant genotype by race interaction was found for Cri...... A significant genotype by race interaction was found for Criterion D symptoms. Given the repeated post-hoc tests, the family wise alpha level was adjusted to p<0.017 (dividing 0.05 by 3 [for the three symptom clusters]) to determine statistical significance. Even following this adjustment, the above-cited p value for the interaction of genotype and race for Criterion D symptoms remained statistically significant. More... Significant
rs4680 Total PTSD symptoms COMT Race Wald X2=15.45, P-value<0.001 A significant COMT genotype by race interaction was found in...... A significant COMT genotype by race interaction was found in predicting total PTSD symptoms. More... Significant
rs4680 PTSD category C symptom COMT Race Wald X2=4.22, P-value=0.12 Subsequent analyses within symptom clusters demonstrated tha...... Subsequent analyses within symptom clusters demonstrated that the genotype by race interaction was not significant for Criterion C symptoms. More... Non-significant
rs4680 PTSD category B symptom COMT Race Wald X2=2.94, P-value=0.23 Subsequent analyses within symptom clusters demonstrated tha...... Subsequent analyses within symptom clusters demonstrated that the genotype by race interaction was not significant for Criterion B symptoms. More... Non-significant