SNP Report
Basic Info
| Name | rs518425 dbSNP Ensembl | ||
|---|---|---|---|
| Location | 15:78591471 - 78591471(+) | ||
| Variant Seq | G | ||
| Ancestral Allele | A | ||
| Ref Seq | A | ||
| Minor Allele Frequence | 0.454073 | ||
| Annotation | downstream_gene_variant; upstream_gene_variant; intron_variant | ||
| Variant Effect | downstream_gene_variant(ENST00000559002, ENST00000348639, ENST00000559658, ENST00000326828); upstream_gene_variant(ENST00000567141); intron_variant(ENST00000299565, ENST00000559576, ENST00000394802, ENST00000559554) | ||
| SIFT Annotation | deleterious | ||
| SIFT Variant Effect | deleterious(ENST00000299565) | ||
| PolyPhen Annotation | probably_damaging | ||
| PolyPhen Variant Effect | probably_damaging(ENST00000299565) | ||
| rSNP? | Yes Link in rVarBase | ||
| Related Regulatory Elements | Chromatin interactive region | ||
| Chromatin State | Weak transcription | ||
| No. of Marker's Association Results | 1 (Positive: 0; Negative: 1; Trend: 0) | ||
| Source | Literature | ||
SNP related association results
| Reference | Phenotype | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | In 2179 MRS subjects of European descent: P-value=0.07. In 2179 MRS subjects of European descent: P-value=0.07. | No significant result. No significant result. | Non-significant |
G*E study related association result (count: 1)
| Reference | Phenotype | Environment | Statistical Values | Author Comments | Marker's Category |
|---|---|---|---|---|---|
| Nievergelt, C. M.,2015 | PTSD | Childhood trauma | In 2179 MRS subjects of European descent, gene and childhood...... In 2179 MRS subjects of European descent, gene and childhood trauma interaction: P-value<0.05. More... | It showed a non-significant interaction effect with childhoo...... It showed a non-significant interaction effect with childhood trauma on PTSD. More... | Non-significant |
SNP related genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Association Results (Positive/Negative/Trend)  |
|---|---|---|---|
| CHRNA3 | cholinergic receptor, nicotinic alpha 3 | 15q24 | 1(0/1/0) |
| CHRNA5 | cholinergic receptor, nicotinic alpha 5 | 15q24 | 2(1/1/0) |
SNPs in LD with rs518425 (count: 7)
Literature-origin SNPs (count: 0)
LD-proxies (count: 7)
SNP related eQTL (count: 1)