Gene Report

Basic Info

Approved Symbol	SRD5A2
Approved Name	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
Location	2p23.1
Position	chr2:31522480-31581067, -1
External Links	HGNC: 11285 Entrez Gene: 6716 Ensembl: ENSG00000277893 UCSC: uc032nip.1
No. of Association Results	11 (Positive: 11; Negative: 0; trend: 0)
Annotation Type	Literature-origin, Mapped by Literature SNP, Mapped by LD-proxy

Gene related association results

Normal genetic study related association results (count: 11)

Reference	Phenotype	Marker	Gene's Category
Gillespie, Charles F.,2013	Avoidance/Numbing symptoms	rs523349	Significant
Gillespie, Charles F.,2013	Hyperarousal symptoms	rs523349	Significant
Gillespie, Charles F.,2013	Intrusive/Reexperiencing symptoms	rs523349	Significant
Gillespie, Charles F.,2013	Proxy-diagnosis of PTSD	rs523349	Significant
Gillespie, C. F.,2013	PSS avoidance/numbing subscale	rs523349	Significant
Gillespie, C. F.,2013	PSS hyperarousal subscale	rs523349	Significant
Gillespie, C. F.,2013	PSS intrusive/reexperiencing subscale	rs523349	Significant
Nievergelt, C. M.,2015	PTSD	rs77929608	Significant
Gillespie, C. F.,2013	PTSD diagnosis	rs523349	Significant
Gillespie, C. F.,2013	Total PSS score	rs523349	Significant
Gillespie, Charles F.,2013	Total PTSD symptoms	rs523349	Significant

G*E study related association result (count: 1)

Reference	Phenotype	Environment	Marker	Gene's Category
Gillespie, Charles F.,2013	Proxy-diagnosis of PTSD	Sex	rs523349 ; rs77929608	Significant

Gene functional annotation

Gene related GO terms (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in PTSDgene
GO:0032354	response to follicle-stimulating hormone	biological process	IEA	1
GO:0055114	oxidation-reduction process	biological process	IEA	18
GO:0009917	sterol 5-alpha reductase activity	molecular function	IDA[1944596]	1
GO:0044281	small molecule metabolic process	biological process	TAS	38
GO:0031667	response to nutrient levels	biological process	IEA	3
GO:0021766	hippocampus development	biological process	IEA	1
GO:0033574	response to testosterone	biological process	IEA	3
GO:0008584	male gonad development	biological process	IMP[1944596]	2
GO:0006706	steroid catabolic process	biological process	IEA	1
GO:0018879	biphenyl metabolic process	biological process	IEA	1
GO:0060348	bone development	biological process	IEA	1
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	13
GO:0030539	male genitalia development	biological process	IEA	1
GO:0030154	cell differentiation	biological process	IEA	10
GO:0021854	hypothalamus development	biological process	IEA	2
GO:0007267	cell-cell signaling	biological process	TAS[1944596]	10
GO:0047751	cholestenone 5-alpha-reductase activity	molecular function	IEA	1
GO:0018894	dibenzo-p-dioxin metabolic process	biological process	IEA	1
GO:0043025	neuronal cell body	cellular component	IEA	18
GO:0070852	cell body fiber	cellular component	IEA	4
GO:0018963	phthalate metabolic process	biological process	IEA	2
GO:0033218	amide binding	molecular function	IEA	1
GO:0043434	response to peptide hormone	biological process	IEA	6
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity	molecular function	IEA	1
GO:0016021	integral component of membrane	cellular component	IEA	56
GO:0030540	female genitalia development	biological process	IEA	1
GO:0042493	response to drug	biological process	IEA	25
GO:0008202	steroid metabolic process	biological process	TAS	2
GO:0008209	androgen metabolic process	biological process	IDA[1944596]	1
GO:0006702	androgen biosynthetic process	biological process	TAS	1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in PTSDgene
hsa00120	Bile acid biosynthesis	1
hsa00150	Androgen and estrogen metabolism	2
hsa05215	Prostate cancer	3

Gene related interactors from protein-protein interactions data in PINA v2 (count: 0)